• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Rapamycin protects aging muscle.

作者信息

Tang Huibin, Shrager Joseph B, Goldman Daniel

机构信息

Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA.

出版信息

Aging (Albany NY). 2019 Aug 27;11(16):5868-5870. doi: 10.18632/aging.102176.

DOI:10.18632/aging.102176
PMID:31454792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6738401/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee90/6738401/9ef7be250765/aging-11-102176-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee90/6738401/9ef7be250765/aging-11-102176-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee90/6738401/9ef7be250765/aging-11-102176-g001.jpg

相似文献

1
Rapamycin protects aging muscle.雷帕霉素可保护衰老肌肉。
Aging (Albany NY). 2019 Aug 27;11(16):5868-5870. doi: 10.18632/aging.102176.
2
The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes.褪黑素对与年龄相关的、与肌肉减少症相关的管状聚集形成、乳酸耗竭和线粒体变化的保护作用。
J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1330-1338. doi: 10.1093/gerona/gly059.
3
The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia.神经肌肉接点是肌肉减少症中 mTORC1 信号的焦点。
Nat Commun. 2020 Sep 9;11(1):4510. doi: 10.1038/s41467-020-18140-1.
4
Partial Inhibition of mTORC1 in Aged Rats Counteracts the Decline in Muscle Mass and Reverses Molecular Signaling Associated with Sarcopenia.在老年大鼠中部分抑制 mTORC1 可逆转与肌肉减少症相关的肌肉质量下降和分子信号。
Mol Cell Biol. 2019 Sep 11;39(19). doi: 10.1128/MCB.00141-19. Print 2019 Oct 1.
5
The physiopathologic role of oxidative stress in skeletal muscle.氧化应激在骨骼肌中的病理生理作用。
Mech Ageing Dev. 2018 Mar;170:37-44. doi: 10.1016/j.mad.2017.08.009. Epub 2017 Aug 26.
6
The Impact of Antidiabetic Agents on Sarcopenia in Type 2 Diabetes: A Literature Review.抗糖尿病药物对 2 型糖尿病患者肌少症的影响：文献综述。
J Diabetes Res. 2020 Jul 9;2020:9368583. doi: 10.1155/2020/9368583. eCollection 2020.
7
The endocrine system and sarcopenia: potential therapeutic benefits.内分泌系统与肌肉减少症：潜在的治疗益处。
Curr Aging Sci. 2011 Dec;4(3):298-305. doi: 10.2174/1874609811104030298.
8
With oxytocin, old muscles act like new.有了催产素，老化的肌肉能恢复活力。
Lab Anim (NY). 2014 Aug;43(8):260. doi: 10.1038/laban.599.
9
The curious case of anabolic resistance: old wives' tales or new fables?合成代谢抵抗的离奇案例：无稽之谈还是新的传说？
J Appl Physiol (1985). 2012 Apr;112(7):1233-5. doi: 10.1152/japplphysiol.01343.2011. Epub 2011 Dec 1.
10
Commentaries on viewpoint: the curious case of anabolic resistance: old wives' tales or new fables?观点评论：合成代谢抵抗的离奇案例：无稽之谈还是新的寓言？
J Appl Physiol (1985). 2012 Apr;112(7):1236. doi: 10.1152/japplphysiol.00097.2012.

引用本文的文献

1
Mitochondrial DNA Deletion Mutations: A Molecular Cause of Age-Induced Skeletal Muscle Fiber Dysfunction and Fiber Death Contributing to Sarcopenia.线粒体DNA缺失突变：年龄诱导的骨骼肌纤维功能障碍和纤维死亡导致肌肉减少症的分子原因。
Adv Exp Med Biol. 2025;1478:343-363. doi: 10.1007/978-3-031-88361-3_14.
2
Mechanisms Underlying Muscle-Related Diseases and Aging: Insights into Pathophysiology and Therapeutic Strategies.肌肉相关疾病与衰老的潜在机制：对病理生理学和治疗策略的见解
Muscles. 2025 Jul 31;4(3):26. doi: 10.3390/muscles4030026.
3
Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise.

本文引用的文献

1
mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.mTORC1通过诱导氧化应激和分解代谢导致与年龄相关的肌纤维损伤和丧失。
Aging Cell. 2019 Jun;18(3):e12943. doi: 10.1111/acel.12943. Epub 2019 Mar 29.
2
mTOR as a central hub of nutrient signalling and cell growth.mTOR 作为营养信号和细胞生长的中央枢纽。
Nat Cell Biol. 2019 Jan;21(1):63-71. doi: 10.1038/s41556-018-0205-1. Epub 2019 Jan 2.
3
mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases.mTORC 抑制剂作为治疗与年龄相关疾病的广谱疗法。
选择哪种方法来对抗肌肉骨骼衰老？关于运动多重效应的综合综述
Int J Mol Sci. 2025 Aug 5;26(15):7573. doi: 10.3390/ijms26157573.
4
The Mitochondria-Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age.线粒体靶向肽治疗药物艾拉米肽可改善衰老过程中的心脏和骨骼肌功能，而组织表观遗传或转录组年龄无明显变化。
Aging Cell. 2025 Mar 13:e70026. doi: 10.1111/acel.70026.
5
The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age.线粒体靶向肽疗法依拉米肽可改善衰老过程中心脏和骨骼肌功能，而组织表观遗传或转录组年龄无明显变化。
bioRxiv. 2024 Oct 31:2024.10.30.620676. doi: 10.1101/2024.10.30.620676.
6
Challenging Sarcopenia: Exploring AdipoRon in Aging Skeletal Muscle as a Healthspan-Extending Shield.挑战肌肉减少症：探索衰老骨骼肌中的AdipoRon作为延长健康寿命的保护因子
Antioxidants (Basel). 2024 Sep 3;13(9):1073. doi: 10.3390/antiox13091073.
7
Skeletal muscle dysfunction with advancing age.随着年龄的增长，骨骼肌功能逐渐衰退。
Clin Sci (Lond). 2024 Jul 17;138(14):863-882. doi: 10.1042/CS20231197.
8
Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies.肌肉减少症的研究进展：机制、治疗靶点和干预策略。
Arch Pharm Res. 2024 Apr;47(4):301-324. doi: 10.1007/s12272-024-01493-2. Epub 2024 Apr 9.
9
Rapamycin protects mouse skin from ultraviolet B-induced photodamage by modulating Hspb2-mediated autophagy and apoptosis.雷帕霉素通过调节 Hspb2 介导线粒体自噬和凋亡保护小鼠皮肤免受紫外线 B 诱导的光损伤。
Mol Biol Rep. 2024 Jan 6;51(1):80. doi: 10.1007/s11033-023-08954-9.
10
Age Is Just a Number: Progress and Obstacles in the Discovery of New Candidate Drugs for Sarcopenia.年龄只是一个数字：肌少症新候选药物发现的进展和障碍。
Cells. 2023 Nov 11;12(22):2608. doi: 10.3390/cells12222608.
Int J Mol Sci. 2018 Aug 8;19(8):2325. doi: 10.3390/ijms19082325.
4
mTOR Signaling in Growth, Metabolism, and Disease.生长、代谢及疾病中的mTOR信号传导
Cell. 2017 Apr 6;169(2):361-371. doi: 10.1016/j.cell.2017.03.035.
5
Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy.持续激活 mTORC1 会抑制骨骼肌的组成型和饥饿诱导的自噬，并导致严重的、迟发性肌病。
Cell Metab. 2013 May 7;17(5):731-44. doi: 10.1016/j.cmet.2013.03.015. Epub 2013 Apr 18.
6
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.在生命后期喂食雷帕霉素可延长基因异质小鼠的寿命。
Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.
7
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo.Akt/mTOR信号通路是骨骼肌肥大的关键调节因子，并且在体内可预防肌肉萎缩。
Nat Cell Biol. 2001 Nov;3(11):1014-9. doi: 10.1038/ncb1101-1014.