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Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease.

作者信息

Panicker Nikhil, Kanthasamy Arthi, Kanthasamy Anumantha G

机构信息

Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

出版信息

Aging (Albany NY). 2019 Aug 27;11(16):5871-5873. doi: 10.18632/aging.102210.

DOI:10.18632/aging.102210
PMID:31454793
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6738402/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39fe/6738402/34b93e6edfec/aging-11-102210-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39fe/6738402/34b93e6edfec/aging-11-102210-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39fe/6738402/34b93e6edfec/aging-11-102210-g001.jpg

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本文引用的文献

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Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.Fyn 激酶调节微胶质细胞中错误折叠的 α-突触核蛋白摄取和 NLRP3 炎性小体的激活。
J Exp Med. 2019 Jun 3;216(6):1411-1430. doi: 10.1084/jem.20182191. Epub 2019 Apr 29.
2
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.炎症小体抑制可预防小鼠 α-突触核蛋白病和多巴胺能神经退行性变。
Sci Transl Med. 2018 Oct 31;10(465). doi: 10.1126/scitranslmed.aah4066.
3
Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease.
有机磷酸酯、二异丙基氟磷酸酯（DFP）中毒及口服萨拉卡替尼后肠道菌群失调。
Front Microbiomes. 2022;1. doi: 10.3389/frmbi.2022.1006078. Epub 2022 Oct 20.
4
Saracatinib, a Src Tyrosine Kinase Inhibitor, as a Disease Modifier in the Rat DFP Model: Sex Differences, Neurobehavior, Gliosis, Neurodegeneration, and Nitro-Oxidative Stress.萨拉卡替尼，一种Src酪氨酸激酶抑制剂，在大鼠二异丙基氟磷酸酯（DFP）模型中作为疾病修饰剂：性别差异、神经行为、胶质细胞增生、神经退行性变和硝基氧化应激。
Antioxidants (Basel). 2021 Dec 28;11(1):61. doi: 10.3390/antiox11010061.
5
Differential Impact of Severity and Duration of , Medical Countermeasures, and a Disease-Modifier, Saracatinib, on Brain Regions in the Rat Diisopropylfluorophosphate Model.在大鼠二异丙基氟磷酸酯模型中，医学对策、疾病修饰剂萨拉卡替尼的严重程度和持续时间对脑区的差异影响。
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Fyn激酶在帕金森病细胞培养和动物模型中调节小胶质细胞神经炎症反应。
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Interleukin-1β in Central Nervous System Injury and Repair.中枢神经系统损伤与修复中的白细胞介素-1β
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Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.常见的 HLA 区域内的遗传变异与晚发性散发性帕金森病有关。
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Neurobiol Dis. 2010 Mar;37(3):510-8. doi: 10.1016/j.nbd.2009.11.004. Epub 2009 Nov 10.
7
Synuclein activates microglia in a model of Parkinson's disease.在帕金森病模型中，突触核蛋白激活小胶质细胞。
Neurobiol Aging. 2008 Nov;29(11):1690-701. doi: 10.1016/j.neurobiolaging.2007.04.006. Epub 2007 May 29.