Cartwright Steven J
DiagnOx Laboratory, Cherwell Innovation Centre, Upper Heyford, Oxon, United Kingdom.
Homeopathy. 2020 Feb;109(1):14-22. doi: 10.1055/s-0039-1693985. Epub 2019 Aug 27.
Homeopathic potencies have been shown to interact with a range of solvatochromic dyes to produce spectroscopic changes in the visible region of the electromagnetic spectrum. Furthermore, the nature of the changes observed under different experimental conditions is beginning to limit the number of possible hypotheses that can be put forward regarding the fundamental identity of potencies.
The present study uses β-cyclodextrins to encapsulate solvatochromic dyes of widely varying structures. The purpose of this approach is to de-couple the primary dye-potency interaction from any subsequent aggregation effects.
Despite large differences in molecular structure between dyes, results show that potencies affect all dyes according to the same fundamental principles. Specifically, positively and negatively solvatochromic dyes collectively respond in opposite and complementary ways to potencies in accordance with the differential stabilisation of their excited and ground electronic states. Under the conditions of encapsulation, positively solvatochromic dyes display a bathochromic shift of, on average, 0.4 nm with a 2% absorbance change, and negatively solvatochromic dyes display a hypsochromic shift of, on average, 0.2 nm with a 1% absorbance change. This behaviour is only ever seen in two situations-where solvent becomes more polar or where an electric field is applied to solutions of dyes.
The conditions used in this and previous studies to investigate the interaction of potencies with solvatochromic dyes preclude increased polarity of solvent as being responsible for the observed effects and that an explanation in which potencies carry an electric field (or electric field-like) component is by far the more likely. From the magnitude of the spectral changes induced in the dye Brooker's merocyanine by 10M, an estimate of the strength of the postulated electric field of 1.16 × 10 V/m can be made, which is comparable with the potential difference across cell membranes.
顺势疗法药力已被证明可与一系列溶剂化显色染料相互作用，从而在电磁光谱的可见光区域产生光谱变化。此外，在不同实验条件下观察到的变化性质，开始限制了就药力的基本特性所能提出的可能假设的数量。
本研究使用β-环糊精来包封结构差异很大的溶剂化显色染料。这种方法的目的是将染料与药力之间的主要相互作用，与任何后续的聚集效应分离开来。
尽管染料之间的分子结构差异很大，但结果表明，药力根据相同的基本原理影响所有染料。具体而言，正溶剂化显色染料和负溶剂化显色染料根据其激发态和基态电子态的不同稳定性，以相反且互补的方式共同对药力作出反应。在包封条件下，正溶剂化显色染料平均显示0.4nm的红移，吸光度变化为2%，负溶剂化显色染料平均显示0.2nm的蓝移，吸光度变化为1%。这种行为仅在两种情况下出现——溶剂极性增加时，或对染料溶液施加电场时。
本研究及先前研究中用于探究药力与溶剂化显色染料相互作用的条件，排除了溶剂极性增加是观察到的效应的原因，而且药力带有电场（或类似电场）成分的解释，目前看来可能性要大得多。根据10M的布鲁克隐色菁染料诱导的光谱变化幅度，可以估计出假定电场强度为1.16×10V/m，这与细胞膜上的电位差相当。
