Cartwright Steven J
DiagnOx Laboratory, Cherwell Innovation Centre, Upper Heyford, Oxon, OX25 5HD, UK.
Homeopathy. 2017 Feb;106(1):37-46. doi: 10.1016/j.homp.2017.01.001. Epub 2017 Feb 13.
Previous studies have demonstrated the potential of solvatochromic dyes for investigating the physical chemistry of homeopathic potencies.
Following examination of this class of dyes in organic solvents, results obtained using the positively solvatochromic dye Bis-dimethylaminofuchsone (BDF) in aqueous solution are now reported. Spectral changes observed with this dye in the presence of potencies are both substantial and reproducible. Studies across a wide range of pH values reveal an unusual pH dependence for the dye's interaction with homeopathic potencies. Results indicate potency enhances dye protonation at pH values below c. 7.0, whilst protecting the dye from attack by hydroxyl ions above c. pH 7.5.
A possible explanation for these observations is offered in terms of a potency - induced electron density shift in BDF. The interaction of homeopathic potencies with solvatochromic dyes, particularly BDF, points towards a possible physico-chemical model for the nature of potencies, how they may be interacting with this class of dyes, and moreover how their biological effects may be mediated.
先前的研究已经证明了溶剂化显色染料在研究顺势疗法药力物理化学性质方面的潜力。
在对这类染料在有机溶剂中进行检测之后，现在报告使用正溶剂化显色染料双二甲基氨基富酮（BDF）在水溶液中获得的结果。在药力存在的情况下，用这种染料观察到的光谱变化既显著又可重复。在广泛的pH值范围内进行的研究揭示了该染料与顺势疗法药力相互作用的一种不寻常的pH依赖性。结果表明，在pH值低于约7.0时，药力会增强染料的质子化，而在pH值高于约7.5时，则会保护染料免受氢氧根离子的攻击。
根据BDF中药力诱导的电子密度变化，对这些观察结果提供了一种可能的解释。顺势疗法药力与溶剂化显色染料，特别是BDF的相互作用，指向了一个关于药力性质、它们可能如何与这类染料相互作用以及它们的生物学效应可能如何介导的物理化学模型。
