Ozkan Ugur, Ozcelik Fatih, Yildiz Mustafa, Budak Metin
Department of Cardiology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey.
Department of Cardiology, Edirne Sultan 1. Murat State Hospital, 22030 Edirne, Turkey.
J Cardiovasc Dev Dis. 2019 Aug 26;6(3):31. doi: 10.3390/jcdd6030031.
Calcific aortic valve disease (CAVD) is a multifactorial condition. Both environmental andgenetic factors play an important role in its etiology. CAVD exhibits a broad spectrum, varying frommild valve thickening to severe valve calcification and stenosis. Progression of the disease consistsof chronic inflammation, lipoprotein deposition, and active leaflet calcification. It is a process similarto coronary artery disease. In this study, we investigated Lp(a) levels and gene polymorphismsassociated with calcific aortic stenosis from blood samples after echocardiography in the evaluationof 75 patients diagnosed with CAVD and 77 controls. Blood tests were run in our laboratory to ruleout certain risk factors before echocardiography examination. A significant association amongsmoking, elevated LDL level and creatinine, low albumin levels, Lp(a) level, rs10455872, andrs3798220 polymorphisms may be considered genetic risk factors for the development of calcificaortic stenosis.
钙化性主动脉瓣疾病（CAVD）是一种多因素疾病。环境因素和遗传因素在其病因中均起重要作用。CAVD表现出广泛的范围，从轻度瓣膜增厚到严重的瓣膜钙化和狭窄。疾病进展包括慢性炎症、脂蛋白沉积和瓣叶主动钙化。这是一个与冠状动脉疾病相似的过程。在本研究中，我们在对75例诊断为CAVD的患者和77例对照进行超声心动图检查后，从血液样本中调查了与钙化性主动脉瓣狭窄相关的Lp(a)水平和基因多态性。在超声心动图检查前，我们实验室进行了血液检测以排除某些危险因素。吸烟、低密度脂蛋白水平升高和肌酐、低白蛋白水平、Lp(a)水平、rs10455872和rs3798220多态性之间的显著关联可能被视为钙化性主动脉瓣狭窄发生的遗传危险因素。
