Mathieu Patrick, Arsenault Benoit J, Boulanger Marie-Chloé, Bossé Yohan, Koschinsky Marlys L
a Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery , Laval University , Quebec , QC , Canada.
b Quebec Heart and Lung Institute/Department of Medicine , Laval University , Quebec , QC , Canada.
Expert Rev Cardiovasc Ther. 2017 Oct;15(10):797-807. doi: 10.1080/14779072.2017.1367286. Epub 2017 Aug 24.
Calcific aortic valve disease (CAVD) is the most prevalent heart valve disorder. Gene variant in the LPA gene, which encodes for apolipoprotein(a), has been associated at the genome-wide level with CAVD. The process whereby Lp(a) promotes the development of CAVD is under intensive investigation and recent data have shed important insights into disease biology. In this regard, autotaxin (ATX), a lysophospholipase D, interacts with Lp(a) and promotes the mineralization of the aortic valve. Areas covered: In this paper, we are reviewing the biology of Lp(a) and the latest discoveries about the molecular processes that link this lipoprotein with the development of CAVD including the role of ATX. Expert commentary: Elevated Lp(a) levels are genetically determined and considered as an important risk factor for CAVD. Understanding how Lp(a) promotes the development/progression of CAVD is crucial as it may hold promise for the development of new therapies.
钙化性主动脉瓣疾病（CAVD）是最常见的心脏瓣膜疾病。编码载脂蛋白(a)的LPA基因中的基因变异在全基因组水平上与CAVD相关。Lp(a)促进CAVD发展的过程正在深入研究中，最近的数据为疾病生物学提供了重要见解。在这方面，自分泌运动因子（ATX），一种溶血磷脂酶D，与Lp(a)相互作用并促进主动脉瓣矿化。涵盖领域：在本文中，我们回顾了Lp(a)的生物学特性以及关于将这种脂蛋白与CAVD发展联系起来的分子过程的最新发现，包括ATX的作用。专家评论：Lp(a)水平升高由基因决定，被认为是CAVD的重要危险因素。了解Lp(a)如何促进CAVD的发展/进展至关重要，因为这可能为新疗法的开发带来希望。
