Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, No.1166 Liutai Avenue, Chengdu 611137, China.
Biomolecules. 2019 Aug 26;9(9):415. doi: 10.3390/biom9090415.
develops a symbiont relationship with and this association involves a number of signaling pathways and proteomic responses between both partners. In our previous study, we have reported that polysaccharide fraction (PSF) of . could promote tanshinones accumulation in hairy roots. Consequently, the present data elucidates the broad proteomics changes under treatment of PSF. Furthermore, we reported several previously undescribed and unexpected responses, containing gene expression patterns consistent with biochemical stresses and metabolic patterns inside the host. In summary, the PSF-induced tanshinones accumulation in hairy roots may be closely related to Ca triggering, peroxide reaction, protein phosphorylation, and jasmonic acid (JA) signal transduction, leading to an increase in leucine-rich repeat (LRR) protein synthesis. This results in the changes in basic metabolic flux of sugars, amino acids, and protein synthesis, along with signal defense reactions. The results reported here increase our understanding of the interaction between and and specifically confirm the proteomic responses underlying the activities of PSF.
与 建立共生关系，这种关联涉及到两个伙伴之间的许多信号通路和蛋白质组学反应。在我们之前的研究中，我们已经报道了多糖部分 (PSF) 可以促进 毛状根中丹参酮的积累。因此，目前的数据阐明了 PSF 处理下的广泛蛋白质组学变化。此外，我们还报道了一些以前未描述和意外的反应，包含与宿主内生化应激和代谢模式一致的基因表达模式。总之，PSF 诱导的 毛状根中丹参酮的积累可能与 Ca 触发、过氧化物反应、蛋白质磷酸化和茉莉酸 (JA) 信号转导密切相关，导致富含亮氨酸重复 (LRR) 蛋白的合成增加。这导致糖、氨基酸和蛋白质合成的基本代谢通量发生变化，同时还伴随着信号防御反应。这里报道的结果增加了我们对 与 之间相互作用的理解，并特别证实了 PSF 活性所涉及的蛋白质组学反应。
