Ren Jie, Fu Li, Nile Shivraj Hariram, Zhang Jun, Kai Guoyin
Institute of Plant Biotechnology, School of Life Sciences, Shanghai Normal University, Shanghai, China.
Laboratory of Medicinal Plant Biotechnology, College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China.
Front Pharmacol. 2019 Jul 5;10:753. doi: 10.3389/fphar.2019.00753. eCollection 2019.
Bioactive chemical constitutes from the root of classified in two major groups, viz., liposoluble tanshinones and water-soluble phenolics. Tanshinone IIA is a major lipid-soluble compound having promising health benefits. The and studies showed that the tanshinone IIA and salvianolate have a wide range of cardiovascular and other pharmacological effects, including antioxidative, anti-inflammatory, endothelial protective, myocardial protective, anticoagulation, vasodilation, and anti-atherosclerosis, as well as significantly help to reduce proliferation and migration of vascular smooth muscle cells. In addition, some of the clinical studies reported that the preparations in combination with Western medicine were more effective for treatment of various cardiovascular diseases including angina pectoris, myocardial infarction, hypertension, hyperlipidemia, and pulmonary heart diseases. In this review, we demonstrated the potential applications of , including pharmacological effects of salvianolate, tanshinone IIA, and its water-soluble derivative, like sodium tanshinone IIA sulfonate. Moreover, we also provided details about the clinical applications of preparations in controlling the cardiovascular diseases.
来自[植物名称]根的生物活性化学成分主要分为两大类，即脂溶性丹参酮和水溶性酚类。丹参酮IIA是一种主要的脂溶性化合物，具有良好的健康益处。[相关研究]表明，丹参酮IIA和丹酚酸具有广泛的心血管和其他药理作用，包括抗氧化、抗炎、内皮保护、心肌保护、抗凝、血管舒张和抗动脉粥样硬化，还能显著抑制血管平滑肌细胞的增殖和迁移。此外，一些临床研究报告称，[该植物提取物]制剂与西药联合使用对治疗包括心绞痛、心肌梗死、高血压、高脂血症和肺心病在内的各种心血管疾病更有效。在本综述中，我们阐述了[该植物提取物]的潜在应用，包括丹酚酸、丹参酮IIA及其水溶性衍生物如丹参酮IIA磺酸钠的药理作用。此外，我们还详细介绍了[该植物提取物]制剂在控制心血管疾病方面的临床应用。
