Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, No. 17, Nanchang, 330006, China.
Department of Ophthalmology, Xinjiang People's Hospital, Urumqi, China.
BMC Ophthalmol. 2019 Aug 27;19(1):194. doi: 10.1186/s12886-019-1200-4.
To investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in patients with diabetic macular edema (DME) treated monthly with ranibizumab.
We retrospectively analyzed the medical records of all patients who received intravitreal ranibizumab (IVR) treatment for DME at the First Affiliated Hospital of Nanchang University between December 2015 and December 2017. Clinicopathological parameters, including NLR, were evaluated to identify predictors of better outcomes of IVR monotherapy.
Ninety-one treatment-naïve eyes treated with IVR for DME were retrospectively analyzed in this study. Baseline best-corrected visual acuity (BCVA), neutrophils, NLR, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio were negatively correlated with the changes in BCVA at 24 weeks compared with the baseline, while baseline central retinal thickness and lymphocytes were positively correlated with the changes in BCVA at 24 weeks compared with the baseline. Multiple linear regression analysis revealed that NLR was independently associated with the mean change of BCVA between baseline and week 24. In addition, patients with NLR < 2.27 showed a better improvement in letter score than those with NLR > 2.27.
Pretreatment NLR is independently associated with the BCVA in DME patients treated with IVR, and higher pretreatment NLR may contribute to inferior BCVA outcomes.
研究每月接受雷珠单抗治疗的糖尿病黄斑水肿（DME）患者中性粒细胞与淋巴细胞比值（NLR）的预后价值。
我们回顾性分析了 2015 年 12 月至 2017 年 12 月期间在南昌大学第一附属医院接受玻璃体内雷珠单抗（IVR）治疗的所有 DME 患者的病历。评估包括 NLR 在内的临床病理参数，以确定 IVR 单一疗法更好结果的预测因素。
本研究回顾性分析了 91 例接受 IVR 治疗的 DME 治疗初治眼。与基线相比，基线最佳矫正视力（BCVA）、中性粒细胞、NLR、单核细胞与淋巴细胞比值和血小板与淋巴细胞比值与 24 周时 BCVA 的变化呈负相关，而基线中央视网膜厚度和淋巴细胞与 24 周时 BCVA 的变化呈正相关。多元线性回归分析显示，NLR 与基线至 24 周时 BCVA 的平均变化独立相关。此外，NLR<2.27 的患者比 NLR>2.27 的患者字母评分改善更好。
治疗前 NLR 与 IVR 治疗的 DME 患者的 BCVA 独立相关，较高的治疗前 NLR 可能导致较差的 BCVA 结局。
