Bjorland Siri, Gjerstad Johannes, Schistad Elina, Swanson David M, Røe Cecilie
Faculty of Medicine, University of Oslo, Postboks 1078 Blindern, 0316, Oslo, Norway.
Department of Physical Medicine and Rehabilitation, Oslo University Hospital Ullevål, Postboks 4956 Nydalen, 0424, Oslo, Norway.
BMC Res Notes. 2019 Aug 28;12(1):547. doi: 10.1186/s13104-019-4592-6.
Earlier studies documenting the effect of candidate genes on recovery have seldom taken into consideration the impact of emotional distress. Thus, we aimed to assess the modifying effect of emotional distress on genetic variability as a predictor for pain recovery in lumbar radicular (LRP) and low back pain (LBP).
The study population comprised 201 patients and mean age was 41.7 years. The significant association between MMP9 rs17576 (B = 0.71, 95% CI 0.18 to 1.24, p = 0.009) and pain recovery remained statistically significant after adjusting for pain intensity at baseline, age, gender, smoking, body mass index, pain localization and emotional distress (B = 0.68, 95% CI 0.18 to 1.18, p = 0.008). In contrast, the association between OPRM1 (B = - 0.85, 95% CI - 1.66 to - 0.05, p = 0.038) and pain recovery was abolished in the multivariate analysis (B = - 0.72, 95% CI - 1.46 to 0.02, p = 0.058). Hence, MMP9 rs17576 and emotional distress independently seem to predict persistent back pain. The predictive effect of OPRM1 rs179971 with regard to the same outcome is probably dependent on other factors including emotional processing. Trial registration The Regional Committee for Medical Research and Ethics reference number 2014/1754.
早期记录候选基因对恢复影响的研究很少考虑情绪困扰的影响。因此，我们旨在评估情绪困扰对基因变异性的调节作用，以此作为腰椎神经根性疼痛（LRP）和下背痛（LBP）疼痛恢复的预测指标。
研究人群包括201名患者，平均年龄为41.7岁。在校正基线疼痛强度、年龄、性别、吸烟、体重指数、疼痛部位和情绪困扰后，MMP9 rs17576与疼痛恢复之间的显著关联仍具有统计学意义（B = 0.71，95%CI 0.18至1.24，p = 0.009）（B = 0.68，95%CI 0.18至1.18，p = 0.008）。相比之下，在多变量分析中，OPRM1与疼痛恢复之间的关联被消除（B = -0.85，95%CI -1.66至-0.05，p = 0.038）（B = -0.72，95%CI -1.46至0.02，p = 0.058）。因此，MMP9 rs17576和情绪困扰似乎独立预测持续性背痛。OPRM1 rs179971对相同结果的预测作用可能取决于包括情绪处理在内的其他因素。试验注册 医学研究与伦理区域委员会参考编号2014/1754。
