Nieves-Moreno M, García-Caride S, Morales-Fernandez L, Martínez-de-la-Casa J M, Sáenz-Francés F, Sánchez-Jean R, Santos-Bueso E, García-Feijoo J
Unidad de Glaucoma, Servicio de Oftalmología, Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC), Madrid, España.
Unidad de Glaucoma, Servicio de Oftalmología, Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC), Madrid, España.
Arch Soc Esp Oftalmol (Engl Ed). 2019 Nov;94(11):536-539. doi: 10.1016/j.oftal.2019.07.010. Epub 2019 Aug 24.
To analyse the association between the thickness of the circumpapillary retinal nerve fibre layer (cpRNFL) and the thickness of the inner macular layers with the mean deviation of the visual field (MD) in children with primary congenital glaucoma (PCG).
A total of 41 children with PGC were included in the study. They all had a complete ophthalmological examination, including visual acuity, intraocular pressure, funduscopy, Octopus™ visual field, as well as circumpapillar and macular spectral domain optical coherence tomography (SD-OCT). SD-OCT with automated segmentation was used to measure the thicknesses and volumes of the macular retinal nerve fibre layer (mRNFL), ganglion cell layer (GCL), and inner plexiform layer.
The mean age was 11.2±3.86 years, and the mean MD was 8.85±6.76dB. The visual field was classified as normal in 46% of the patients, and 20% of the patients had a concentrical restriction of the visual field. A positive correlation was found between between the cup-to-disc ratio and the MD, r=0.51 (P=.004). The correlation between the MD and the cpRNFL was r=-0.63 (P<.001), and r=-0.69 (P<.001) with the GCL.
Inner macular layers thickness and cpRNFL thickness show a good correlation with the mean deviation of the visual field in children with primary congenital glaucoma.
分析原发性先天性青光眼（PCG）患儿视盘周围视网膜神经纤维层（cpRNFL）厚度和黄斑内层厚度与视野平均缺损（MD）之间的相关性。
本研究共纳入41例PCG患儿。他们均接受了全面的眼科检查，包括视力、眼压、眼底镜检查、Octopus™视野检查以及视盘周围和黄斑区的光谱域光学相干断层扫描（SD-OCT）。采用自动分割的SD-OCT测量黄斑视网膜神经纤维层（mRNFL）、神经节细胞层（GCL）和内网状层的厚度及体积。
平均年龄为11.2±3.86岁，平均MD为8.85±6.76dB。46%的患者视野被分类为正常，20%的患者有视野同心性缺损。发现杯盘比与MD之间存在正相关，r=0.51（P=0.004）。MD与cpRNFL之间的相关性为r=-0.63（P<0.001），与GCL的相关性为r=-0.69（P<0.001）。
原发性先天性青光眼患儿黄斑内层厚度和cpRNFL厚度与视野平均缺损显示出良好的相关性。
