Ophthalmology Unit, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain.
Ophthalmology Unit, Hospital Clinico San Carlos, Deptartment of Ophthalmology and ORL, Faculty of Medicine, Universidad Complutense de Madrid, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain.
Eye (Lond). 2018 Aug;32(8):1338-1344. doi: 10.1038/s41433-018-0077-4. Epub 2018 Apr 12.
To compare the diagnostic performance of circumpapillary retinal nerve fiber layer (cpRNFL) analysis versus segmented ganglion cell complex analysis both by spectral-domain optical coherence tomography (SD-OCT) in children with primary congenital glaucoma (PCG).
Participants were 40 children diagnosed with PCG and 60 healthy children. Ophthalmological data collected (for one eye per child) were cup-disc ratio (C/D) and axial length (AL). SD-OCT with automated segmentation was used to measure the thicknesses and volumes of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL). For the cpRNFL measurements conventional S-D OCT software was used and the capacity of each method to discriminate between normal and glaucomatous eyes was compared.
Mean age was 11.20 ± 3.94 years for the glaucoma patients and 10.90 ± 2.46 years for controls (p = 0.64). All measurements were reduced (thinner) in the glaucoma group, significantly so for: cpRNFL, GCL, IPL and outer-superior and outer-inferior quadrant mRNFL. According to their areas under the receiver operating characteristics curve (AUC), temporal superior cpRNFL (0.869) and outer superior GCL (0.840), IPL (0.799), and mRNFL (0.767) showed the better diagnostic capacity. No differences were observed in AUCs for the most discriminatory cpRNFL and macular measurements.
Segmented macular layer analysis shows a good capacity to discriminate between normal and glaucomatous eyes; which is comparable to that of cpRNFL analysis in children with PCG.
比较原发性先天性青光眼（PCG）患儿频域光相干断层扫描（SD-OCT）检测的环周视网膜神经纤维层（cpRNFL）和节段性神经节细胞复合体（GCIPL）分析的诊断性能。
纳入 40 例 PCG 患儿和 60 例健康儿童。收集的眼科数据（每只眼）包括杯盘比（C/D）和眼轴长度（AL）。使用自动分割的 SD-OCT 测量黄斑视网膜神经纤维层（mRNFL）、神经节细胞层（GCL）和内丛状层（IPL）的厚度和体积。使用传统的 S-D OCT 软件进行 cpRNFL 测量，并比较每种方法区分正常眼和青光眼眼的能力。
青光眼组的平均年龄为 11.20±3.94 岁，对照组为 10.90±2.46 岁（p=0.64）。青光眼组的所有测量值均降低（变薄），cpRNFL、GCL、IPL 以及外上和外下象限 mRNFL 显著降低。根据其受试者工作特征曲线下面积（AUC），颞上 cpRNFL（0.869）、外上 GCL（0.840）、IPL（0.799）和 mRNFL（0.767）的诊断能力较好。最具鉴别力的 cpRNFL 和黄斑测量的 AUC 之间没有差异。
节段性黄斑层分析具有良好的区分正常眼和青光眼眼的能力；与 PCG 患儿的 cpRNFL 分析相当。
