Tomita Y, Maeda K, Tagami H
Department of Dermatology, Tohoku University School of Medicine, Sendai.
Tohoku J Exp Med. 1988 Jun;155(2):209-10. doi: 10.1620/tjem.155.209.
Normal human epidermal melanocytes became swollen and more dendritic and the immunoreactive tyrosinase increased markedly when they were cultured for 2 days with 5 microM of histamine. These results suggest that high dermal concentrations of histamine may be responsible for the induction of skin pigmentary changes associated with local proliferation of mast cells such as in urticaria pigmentosa and systemic mastocytosis.
正常人表皮黑素细胞在与5微摩尔组胺一起培养2天后会肿胀且树突增多，免疫反应性酪氨酸酶也会显著增加。这些结果表明，皮肤中高浓度的组胺可能是导致与肥大细胞局部增殖相关的皮肤色素变化的原因，如色素性荨麻疹和系统性肥大细胞增多症。
