皮肤肥大细胞增多症合并发疹性黑素细胞痣和黑色素瘤。是巧合还是发病机制中的联系？
Cutaneous mastocytosis combined with eruptive melanocytic nevi and melanoma. Coincidence or a linkage in the pathogenesis?
作者信息
Donati Pietro, Paolino Giovanni, Donati Michele, Panetta Chiara
机构信息
Dermatopathological Laboratory "San Gallicano Institute of Rome", Via Elio Chianesi, 53, 00158 Rome, Italy;
Dermatologic Clinic, La Sapienza University of Rome, Viale del Policlinico 15, 00186 Rome, Italy.
出版信息
J Dermatol Case Rep. 2014 Sep 30;8(3):70-4. doi: 10.3315/jdcr.2014.1179.
BACKGROUND
Cellular combinations in the same neoplasm can have intriguing physiopathological implications, which may be useful to better understand the biology of the diseases.
MAIN OBSERVATIONS
Urticaria pigmentosa in association with eruptive melanocytic nevi was observed in a female patient. Maculopapular lesions extended at the base of different melanocytic nevi and the histopathological examination revealed the presence of a mast cell population in the papillary and reticular dermis combined with overlying melanocytic nevi. The re-evaluation of a melanoma removed three years before revealed the presence of the same pathological features. Immunohistochemical assays showed a strong positivity to Giemsa, Toluidine blue and CD-117 in the mast cells, while a S-100 reaction was observed in the melanocytic population.
CONCLUSIONS
We discuss possible pathogenetic linkage between cutaneous mastocytosis and melanoma.
背景
同一肿瘤中的细胞组合可能具有有趣的生理病理学意义，这可能有助于更好地理解疾病的生物学特性。
主要观察结果
在一名女性患者中观察到色素性荨麻疹与发疹性黑素细胞痣相关。斑丘疹病变在不同黑素细胞痣的底部扩展，组织病理学检查显示在乳头层和网状真皮中存在肥大细胞群，并伴有上方的黑素细胞痣。对三年前切除的黑色素瘤进行重新评估，发现存在相同的病理特征。免疫组织化学分析显示肥大细胞对吉姆萨、甲苯胺蓝和CD - 117呈强阳性反应，而在黑素细胞群中观察到S - 100反应。
结论
我们讨论了皮肤肥大细胞增多症与黑色素瘤之间可能的发病机制联系。
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