Lee Jae-Hun, Kim Sehwan, Jung Jae Yun, Lee Min Young
1Interdisciplinary Program for Medical Laser, Dankook University, Cheonan, South Korea.
2Beckman Laser Institute Korea, Dankook University, Cheonan, South Korea.
Biomed Eng Lett. 2019 Jun 18;9(3):351-358. doi: 10.1007/s13534-019-00114-y. eCollection 2019 Aug.
Hearing loss is very common and economically burdensome. No accepted therapeutic modality for sensorineural hearing loss is yet available; most clinicians emphasize rehabilitation, placing hearing aids and cochlear implants. Photobiomodulation (PBM) employs light energy to enhance or modulate the activities of specific organs, and is a popular non-invasive therapy used to treat skin lesions and neurodegenerative disorders. Efforts to use PBM to improve hearing have been ongoing for several decades. Initial in vitro studies using cell lines and ex vivo culture techniques have now been supplanted by in vivo studies in animals; PBM protects the sensory epithelium and triggers neural regeneration. Many reports have used PBM to treat tinnitus. In this brief review, we introduce PBM applications in hearing research, helpful protocols, and relevant background literature.
听力损失非常常见且具有经济负担。目前尚无被广泛认可的感音神经性听力损失治疗方法；大多数临床医生强调康复治疗，主要是佩戴助听器和植入人工耳蜗。光生物调节（PBM）利用光能增强或调节特定器官的活动，是一种用于治疗皮肤损伤和神经退行性疾病的常用非侵入性疗法。几十年来，人们一直在努力利用PBM来改善听力。最初使用细胞系和体外培养技术的体外研究现已被动物体内研究所取代；PBM可保护感觉上皮并触发神经再生。许多报告都使用PBM来治疗耳鸣。在这篇简短的综述中，我们介绍了PBM在听力研究中的应用、有用的方案以及相关的背景文献。
