Zhang Ying, Guo Yijun, Wu Siyao, Liang Haojun, Xu Hangxun
CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China.
ACS Omega. 2017 Jun 7;2(6):2536-2543. doi: 10.1021/acsomega.7b00440. eCollection 2017 Jun 30.
Stimuli-responsive coordination polymer particles (CPPs) show great promise for encapsulating and releasing cargos due to their unique and highly tailorable structures and properties. In particular, photoresponsive CPPs have received enormous interest, as noninvasive light can be spatially and temporally controlled, resulting in great safety and efficiency. In this work, we report the design and synthesis of novel photodegradable CPPs by infinite coordination polymerization of Zn and a photocleavable organic linker containing -nitrobenzyl derivatives. We further demonstrate that these novel photodegradable CPPs are able to efficiently encapsulate cargos and are applicable for on-command drug release upon low-power UV light irradiation (5.78 mW/cm). Because light is a highly desirable remote-trigger and can be used externally, we expect that these photodegradable CPPs can provide a unique platform for controlled cargo release.
刺激响应性配位聚合物颗粒（CPPs）由于其独特且高度可定制的结构和性质，在封装和释放货物方面显示出巨大的潜力。特别是，光响应性CPPs受到了极大的关注，因为无创光可以在空间和时间上进行控制，从而具有很高的安全性和效率。在这项工作中，我们报告了通过锌与含 -硝基苄基衍生物的光可裂解有机连接体的无限配位聚合来设计和合成新型光降解CPPs。我们进一步证明，这些新型光降解CPPs能够有效地封装货物，并适用于在低功率紫外光照射（5.78 mW/cm）时按需释放药物。由于光是一种非常理想的远程触发因素，并且可以在外部使用，我们预计这些光降解CPPs可以为可控货物释放提供一个独特的平台。
