用于手术和伤口敷料的基于琼脂糖生物塑料的药物递送系统。
Agarose bioplastic-based drug delivery system for surgical and wound dressings.
作者信息
Awadhiya Ankur, Tyeb Suhela, Rathore Kalpana, Verma Vivek
机构信息
Department of Biological Sciences and Bioengineering Indian Institute of Technology Kanpur Kanpur India.
Department of Materials Science and Engineering Indian Institute of Technology Kanpur Kanpur India.
出版信息
Eng Life Sci. 2016 Oct 12;17(2):204-214. doi: 10.1002/elsc.201500116. eCollection 2017 Feb.
Abstract
We have developed an agarose-based biocompatible drug delivery vehicle. The vehicle is in the form of thin, transparent, strong and flexible films. The biocompatibility and haemocompatibility of the films is confirmed using direct and indirect contact biological assay. Contact angle measurement exhibits hydrophilic nature of the films, and protein adsorption test shows low protein adsorption on the film surface. Drugs, antibiotics and antiseptics, retain their potency after their incorporation into the films. Our bioplastic films can be a versatile medium for drug delivery applications, especially as wound and surgical dressings where a fast drug release rate is desired.
摘要
我们开发了一种基于琼脂糖的生物相容性药物递送载体。该载体呈薄、透明、坚固且柔韧的薄膜形式。使用直接和间接接触生物测定法确认了薄膜的生物相容性和血液相容性。接触角测量显示薄膜具有亲水性，蛋白质吸附测试表明薄膜表面的蛋白质吸附率较低。药物、抗生素和防腐剂在掺入薄膜后仍保持其效力。我们的生物塑料薄膜可以成为药物递送应用的通用介质，特别是作为需要快速药物释放速率的伤口和手术敷料。
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