通过叠氮乙烯与脒的[3 + 2]环化反应无催化剂合成2,4-二取代-1-咪唑。
Catalyst-Free Synthesis of 2,4-Disubstituted-1-imidazoles through [3 + 2] Cyclization of Vinyl Azides with Amidines.
作者信息
Reddy N Naresh Kumar, Nageswara Rao Sadu, Ravi Chitrakar, Adimurthy Subbarayappa
机构信息
Academy of Scientific & Innovative Research, CSIR-Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar 364002, Gujarat, India.
出版信息
ACS Omega. 2017 Aug 30;2(8):5235-5241. doi: 10.1021/acsomega.7b00969. eCollection 2017 Aug 31.
Abstract
A facile and efficient route for the synthesis of 2,4-disubstituted imidazoles from benzimidamides and vinyl azides through [3 + 2] cyclization under catalyst-free conditions has been described. The method is compatible for a broad range of functional groups with good to excellent yields.
摘要
描述了一种在无催化剂条件下，通过[3 + 2]环化反应，由苯并咪唑酰胺和乙烯基叠氮化物合成2,4-二取代咪唑的简便有效途径。该方法适用于广泛的官能团，产率良好至优异。
Zotero 插件