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通过叠氮乙烯与脒的[3 + 2]环化反应无催化剂合成2,4-二取代-1-咪唑。

Catalyst-Free Synthesis of 2,4-Disubstituted-1-imidazoles through [3 + 2] Cyclization of Vinyl Azides with Amidines.

作者信息

Reddy N Naresh Kumar, Nageswara Rao Sadu, Ravi Chitrakar, Adimurthy Subbarayappa

机构信息

Academy of Scientific & Innovative Research, CSIR-Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar 364002, Gujarat, India.

出版信息

ACS Omega. 2017 Aug 30;2(8):5235-5241. doi: 10.1021/acsomega.7b00969. eCollection 2017 Aug 31.

DOI:10.1021/acsomega.7b00969
PMID:31457795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6641739/
Abstract

A facile and efficient route for the synthesis of 2,4-disubstituted imidazoles from benzimidamides and vinyl azides through [3 + 2] cyclization under catalyst-free conditions has been described. The method is compatible for a broad range of functional groups with good to excellent yields.

摘要

描述了一种在无催化剂条件下，通过[3 + 2]环化反应，由苯并咪唑酰胺和乙烯基叠氮化物合成2,4-二取代咪唑的简便有效途径。该方法适用于广泛的官能团，产率良好至优异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4907/6641739/742d2052c958/ao-2017-00969n_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4907/6641739/75739e9d2dd5/ao-2017-00969n_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4907/6641739/ccd92551c911/ao-2017-00969n_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4907/6641739/1a09e30d5496/ao-2017-00969n_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4907/6641739/b4be4963c0ed/ao-2017-00969n_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4907/6641739/7d2acb396f59/ao-2017-00969n_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4907/6641739/742d2052c958/ao-2017-00969n_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4907/6641739/75739e9d2dd5/ao-2017-00969n_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4907/6641739/ccd92551c911/ao-2017-00969n_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4907/6641739/1a09e30d5496/ao-2017-00969n_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4907/6641739/b4be4963c0ed/ao-2017-00969n_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4907/6641739/7d2acb396f59/ao-2017-00969n_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4907/6641739/742d2052c958/ao-2017-00969n_0006.jpg

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