Chen Xiao Yun, Englert Ulli, Bolm Carsten
Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany).
Institut für Anorganische Chemie, RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany).
Chemistry. 2015 Sep 14;21(38):13221-4. doi: 10.1002/chem.201502707.
A new transition metal-free method for the preparation of substituted imidazoles from easy-to-handle amidine hydrochlorides and bromoacetylenes has been developed. The reactions proceed in air and use inexpensive K2 CO3 as base. Additions of 2,2'-bipyridine and water have beneficial effects on the product yields. Various di- and trisubstituted imidazoles have been prepared in good yields (up to 88 %).
