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通过逐步和一锅法形成异恶唑并吡啶/N-O键断裂序列，由4-炔丙基氨基异恶唑合成3-羟基-4-取代吡啶腈。

Synthesis of 3-Hydroxy-4-Substituted Picolinonitriles from 4-Propargylaminoisoxazoles via Stepwise and One-Pot Isoxazolopyridine Formation/N-O Bond Cleavage Sequence.

作者信息

Fukuhara Shintaro, Yugandar Somaraju, Fuse Shinichiro, Nakamura Hiroyuki

机构信息

Laboratory for Chemistry and Life Science, Institute of Innovative Research, School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan.

出版信息

ACS Omega. 2018 Dec 3;3(12):16472-16476. doi: 10.1021/acsomega.8b03114. eCollection 2018 Dec 31.

DOI:10.1021/acsomega.8b03114
PMID:31458282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6644211/
Abstract

A unique synthetic approach to 3-hydroxy-4-substituted picolinonitriles is achieved via gold(I)-catalyzed cyclization of 4-propargylaminoisoxazoles and subsequent N-O bond cleavage of isoxazolopyridines under mild reaction conditions in a stepwise and one-pot fashion.

摘要

通过金（I）催化的4-炔丙基氨基异恶唑环化反应以及随后在温和反应条件下以逐步和一锅法进行的异恶唑并吡啶的N-O键裂解，实现了一种独特的合成3-羟基-4-取代吡啶腈的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/6644211/c7b1ac530981/ao-2018-03114b_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/6644211/63b07b8fd4d4/ao-2018-03114b_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/6644211/26d4f8b85a34/ao-2018-03114b_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/6644211/c7b1ac530981/ao-2018-03114b_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/6644211/63b07b8fd4d4/ao-2018-03114b_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/6644211/26d4f8b85a34/ao-2018-03114b_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e980/6644211/c7b1ac530981/ao-2018-03114b_0006.jpg

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