铑催化肼与炔烃的加成环化反应：通过意外的C-N键断裂合成吡唑
Rhodium-catalyzed addition-cyclization of hydrazines with alkynes: pyrazole synthesis via unexpected C-N bond cleavage.
作者信息
Li Deng Yuan, Mao Xiao Feng, Chen Hao Jie, Chen Guo Rong, Liu Pei Nian
机构信息
Shanghai Key Laboratory of Functional Materials Chemistry, Key Lab for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
出版信息
Org Lett. 2014 Jul 3;16(13):3476-9. doi: 10.1021/ol501402p. Epub 2014 Jun 25.
Rhodium-catalyzed addition-cyclization of hydrazines with alkynes has been achieved to afford highly substituted pyrazoles under mild conditions. The cascade reaction involves two transformations: addition of the C-N bond of hydrazines to alkynes via unexpected C-N bond cleavage and intramolecular dehydration cyclization.
铑催化肼与炔烃的加成环化反应已在温和条件下实现，可得到高度取代的吡唑。该串联反应涉及两个转化过程：通过意外的C-N键断裂将肼的C-N键加成到炔烃上，以及分子内脱水环化。
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