Maegawa Tomohiro, Mizui Ryota, Urasaki Miki, Fujimura Kazuma, Nakamura Akira, Miki Yasuyoshi
School of Pharmaceutical Sciences, Kindai University, Higashi-osaka, Osaka 577-8502, Japan.
Research Organization of Science and Technology, Research Center for Drug Discovery and Pharmaceutical Science, Ritsumeikan University, Nojihigashi, Kusatsu, Shiga 525-8577, Japan.
ACS Omega. 2018 May 18;3(5):5375-5381. doi: 10.1021/acsomega.8b00594. eCollection 2018 May 31.
A novel approach for synthesizing chalcones by Pd-catalyzed oxidative coupling is described. This is the first report of the efficient coupling reaction of acetanilides with phenyl vinyl ketones under mild conditions. Selective C-H activation occurred next to the acetamide group to afford 2-aminochalcone derivatives. The reaction proceeded under an O atmosphere without any chemical co-oxidants.
描述了一种通过钯催化氧化偶联合成查耳酮的新方法。这是关于乙酰苯胺与苯乙烯基酮在温和条件下有效偶联反应的首次报道。在乙酰酰胺基团旁边发生选择性C-H活化，得到2-氨基查耳酮衍生物。该反应在氧气气氛下进行，无需任何化学共氧化剂。
