Shi Zhenyu, Hammond Gerald B, Xu Bo
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
Faster Chemistry LLC, Louisville, Kentucky 40218, United States.
ACS Omega. 2018 Jun 21;3(6):6748-6756. doi: 10.1021/acsomega.8b00966. eCollection 2018 Jun 30.
We have developed a substantially faster and greener technique for routine chemical reaction workups. We use silicone elastomer-coated glass powder ("FastWoRX") as an absorbent to extract organic products from a quenched aqueous reaction mixture. After filtration, FastWoRX powder loaded with organic products can serve as a convenient input for flash chromatographic separations. With this technique, tedious and solvent-consuming liquid-liquid extractions are replaced by a simple filtration. Use of FastWoRX reduces solvent use and the -factor by up to an order of magnitude compared to traditional liquid-liquid extraction-based workup.
我们已经开发出一种用于常规化学反应后处理的速度大幅更快且更环保的技术。我们使用涂有硅氧烷弹性体的玻璃粉末（“FastWoRX”）作为吸收剂，从淬灭的水性反应混合物中萃取有机产物。过滤后，负载有机产物的FastWoRX粉末可作为快速柱色谱分离的便捷输入物。通过这种技术，繁琐且消耗溶剂的液 - 液萃取被简单的过滤所取代。与基于传统液 - 液萃取的后处理相比，使用FastWoRX可将溶剂使用量和环境影响因子降低多达一个数量级。
