Turhanen Petri A, Leppänen Jukka, Vepsäläinen Jouko J
School of Pharmacy, Biocenter Kuopio, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland.
ACS Omega. 2019 May 22;4(5):8974-8984. doi: 10.1021/acsomega.9b00790. eCollection 2019 May 31.
The usefulness of dried Dowex H cation-exchange resin with or without sodium iodide (NaI) as a catalyst system for different kinds of esterifications using carboxylic acids and alcohols as starting materials has been systematically investigated. The Dowex H/NaI approach is very effective, generally high yielding, energy-efficient, and nontoxic, and the Dowex H resin is reusable. Since the whole procedure from start to product isolation is also very simple, these features make the method environmentally friendly. The method is regioselective, and its potential for separation of valuable carboxylic acids like resin acids from mixtures containing other kinds of carboxylic acids has been demonstrated. Examples for green and straightforward esterification of highly important natural amino acids are also presented.
已系统研究了带有或不带有碘化钠（NaI）的干燥Dowex H阳离子交换树脂作为催化剂体系，用于以羧酸和醇为起始原料的不同类型酯化反应的效用。Dowex H/NaI方法非常有效，通常产率高、节能且无毒，并且Dowex H树脂可重复使用。由于从开始到产物分离的整个过程也非常简单，这些特性使该方法对环境友好。该方法具有区域选择性，并且已证明其从含有其他种类羧酸的混合物中分离树脂酸等有价值羧酸的潜力。还给出了非常重要的天然氨基酸绿色且直接酯化的实例。
