Qian Jing, Sun Mei-Mei, Liu Ming, Gu Wen
College of Chemistry, Tianjin Key Laboratory of Structure and Performance for Functional Molecules and Key Laboratory of Inorganic-Organic Hybrid Functional Materials Chemistry, Ministry of Education, Tianjin Normal University, Tianjin 300387, P. R. China.
College of Chemistry, Nankai University, Tianjin 300371, P. R. China.
ACS Omega. 2019 Jul 10;4(7):11949-11959. doi: 10.1021/acsomega.8b03326. eCollection 2019 Jul 31.
Reported here are the design and fluorescence characters of a Ni/Tb polymer, [TbNi(HCAM)(HO)] () (HCAM = chelidamic acid). Under physiological conditions, the binding of biocompatible water soluble to human serum albumin (HSA) was studied by spectroscopy techniques, which revealed that could inherent the fluorescent light of HSA in a static quencher course and change the HSA second-level structure. The marked enhancement in and its fluorescence intensity provide conclusive evidence that can play the role of a "turn-on" sensor for recognition and detection of HSA in other biological interferents with a value of 7.68 × 10 M and a detection limit of 0.14 μM. Luminescence experiments show that has high selectivity and sensitivity to MnO in other anions. Its quenching efficiency ( ) is 5.54 × 10 M, and the detection limit is 0.29 μM.
本文报道了一种镍/铽聚合物[TbNi(HCAM)(HO)] （）（HCAM = 白屈氨酸）的设计及荧光特性。在生理条件下，采用光谱技术研究了生物相容性水溶性该聚合物与人血清白蛋白（HSA）的结合情况，结果表明该聚合物能够在静态猝灭过程中固有HSA的荧光，并改变HSA的二级结构。该聚合物及其荧光强度的显著增强提供了确凿证据，表明该聚合物可以作为一种“开启”传感器，在其他生物干扰物中识别和检测HSA，其K值为7.68×10 M，检测限为0.14 μM。发光实验表明，该聚合物在其他阴离子中对MnO 具有高选择性和敏感性。其猝灭效率（）为5.54×10 M，检测限为0.29 μM。
