Osonga Francis J, Akgul Ali, Miller Roland M, Eshun Gaddi B, Yazgan Idris, Akgul Ayfer, Sadik Omowunmi A
Department of Chemistry, Center for Research in Advanced Sensing Technologies & Environmental Sustainability (CREATES), State University of New York at Binghamton, PO Box 6000, Binghamton, New York 13902, United States.
Department of Basic Sciences, College of Veterinary Medicine and Department of Sustainable Bioproducts, College of Forest Resources, Mississippi State University, Starkville, Mississippi 39762, United States.
ACS Omega. 2019 Jul 30;4(7):12865-12871. doi: 10.1021/acsomega.9b00077. eCollection 2019 Jul 31.
The surge of resistant food pathogens is a major threat worldwide. Previous research conducted on phytochemicals has shown their antibacterial activity against pathogenic bacteria. The design of antimicrobial agents to curb pathogenic disease remains a challenge demanding critical attention. Flavonoids such as apigenin and quercetin were evaluated against Gram-positive and Gram-negative bacteria. The results indicated that the antibacterial activity of each flavonoid occurred at a different minimum inhibitory concentration. However, the antimicrobial activity results of the modified flavonoids were also reported, and it was observed that the Gram-positive bacteria were more susceptible in comparison to the Gram-negative bacteria. The cell wall structure of the Gram-positive and Gram-negative bacteria could be the main reason for the bacteria susceptibility. Modified flavonoids could be used as a suitable alternative antimicrobial agent for the treatment of infectious diseases. Our results indicated 100% inhibition of , , and with modified flavonoids.
耐药性食品病原体的激增是全球范围内的一个重大威胁。先前对植物化学物质进行的研究表明它们对病原菌具有抗菌活性。设计抗菌剂以遏制致病性疾病仍然是一个需要高度关注的挑战。对芹菜素和槲皮素等黄酮类化合物针对革兰氏阳性菌和革兰氏阴性菌进行了评估。结果表明，每种黄酮类化合物的抗菌活性在不同的最低抑菌浓度下出现。然而，也报道了改性黄酮类化合物的抗菌活性结果，并且观察到革兰氏阳性菌比革兰氏阴性菌更敏感。革兰氏阳性菌和革兰氏阴性菌的细胞壁结构可能是细菌敏感性的主要原因。改性黄酮类化合物可作为治疗传染病的合适替代抗菌剂。我们的结果表明，改性黄酮类化合物对……、……和……有100%的抑制作用。
