Young R F, Goodman S J
Neurosurgery. 1979 Aug;5(2):225-30. doi: 10.1227/00006123-197908000-00005.
Previously published work indicated significant improvement in the symptoms of multiple sclerosis with dorsal spinal cord stimulation. In this study 23 patients with multiple sclerosis documented by history, examination, laboratory studies, and clinical course were treated with dorsal spinal cord stimulation and followed for 19 to 45 months (mean, 32 months). Pre- and postoperative clinical assessment was carried out using the Kurtzke Scale. Walking velocity, upper limb coordination, sphincter function, and sensory function were also evaluated quantitatively. No statistically significant objective improvement in any of these measures was demonstrated. Fifty per cent of the patients initially reported subjective symptomatic improvement, but this declined to 30% at last follow-up. Fifteen of 23 patients experienced complications related mainly to the hardware used and required a total of 21 subsequent operative procedures for correction of these complications. These results do not support the continued clinical use of dorsal spinal cord stimulation in the symptomatic treatment of multiple sclerosis.
先前发表的研究表明，脊髓背侧刺激可显著改善多发性硬化症的症状。在本研究中，23例经病史、体格检查、实验室检查及临床病程记录确诊的多发性硬化症患者接受了脊髓背侧刺激治疗，并随访19至45个月（平均32个月）。使用库茨克量表进行术前和术后临床评估。还对步行速度、上肢协调性、括约肌功能和感觉功能进行了定量评估。这些指标均未显示出统计学上的显著客观改善。50%的患者最初报告主观症状有所改善，但在最后一次随访时降至30%。23例患者中有15例出现主要与所用硬件相关的并发症，共需要21次后续手术来纠正这些并发症。这些结果不支持继续将脊髓背侧刺激临床用于多发性硬化症的症状治疗。
