Meglio M, Cioni B, Amico E D, Ronzoni G, Rossi G F
Acta Neurochir (Wien). 1980;54(3-4):191-9. doi: 10.1007/BF01407085.
The effect of percutaneous epidural spinal cord stimulation on neurogenic bladder has been evaluated on the basis of objective clinical and urodynamic criteria. Seven patients suffering from stable bladder and sphincter dysfunction due to spinal cord diseases of different causes of non-evolutive nature were examined. In some of them chronic pain or substantially improved micturition in six of our seven patients. Complete or almost complete relief of bladder spasticity, marked increase of bladder capacity, and reduction or abolition of residual urine were recorded. The beneficial effect on bladder and sphincter function is strictly dependent on the stimulation, though it can outlast it. It requires some weeks to reach its maximum. It is still obtained after 22 months of treatment (longest present follow-up). No changes of straital activity and detrusor reflex were produced by spinal cord stimulation in two additional patients, treated for chronic pain but having intact bladder function.
基于客观的临床和尿动力学标准，对经皮硬膜外脊髓刺激对神经源性膀胱的影响进行了评估。对7例因不同病因的非进行性脊髓疾病导致膀胱和括约肌功能稳定障碍的患者进行了检查。在其中一些患者中，慢性疼痛得到缓解，或者我们7例患者中有6例排尿情况显著改善。记录到膀胱痉挛完全或几乎完全缓解、膀胱容量显著增加以及残余尿量减少或消失。对膀胱和括约肌功能的有益作用严格依赖于刺激，尽管这种作用可能会持续超过刺激时间。达到最大效果需要几周时间。在治疗22个月后（目前最长的随访时间）仍可获得这种效果。另外2例因慢性疼痛接受治疗但膀胱功能正常的患者，脊髓刺激未引起纹状体活动和逼尿肌反射的改变。
