金催化由炔基环己二烯酮和取代胺合成6-羟基吲哚
Gold-Catalyzed Synthesis of 6-Hydroxyindoles from Alkynylcyclohexadienones and Substituted Amines.
作者信息
Kadiyala Veerabhushanam, Bharath Kumar Perla, Balasubramanian Sridhar, Karunakar Galla V
机构信息
Fluoro and Agrochemicals Department , Academy of Scientific and Innovative Research , Ghaziabad 201002 , India.
Center for X-ray Crystallography , CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.
出版信息
J Org Chem. 2019 Sep 20;84(18):12228-12236. doi: 10.1021/acs.joc.9b02023. Epub 2019 Sep 11.
An efficient gold-catalyzed formation of 6-hydroxyindoles from substituted alkynylcyclohexadienones and amines have been developed. In this reaction two new C-N bonds were formed, and moderate to very good yields of the 6-hydroxyindole derivatives were obtained in one pot. This organic transformation tolerates a range of substituted alkynylcyclohexadienones and amines, which resulted in 6-hydroxyindole derivatives selectively.
已开发出一种高效的金催化方法，可由取代的炔基环己二烯酮和胺制备6-羟基吲哚。在该反应中形成了两个新的C-N键，并且能一锅法获得中等至非常好产率的6-羟基吲哚衍生物。这种有机转化能够耐受一系列取代的炔基环己二烯酮和胺，从而选择性地生成6-羟基吲哚衍生物。
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