影响苏丹癫痫患者抗癫痫药物依从性的因素：一项横断面调查。
Factors affecting adherence to antiepileptic medications among Sudanese individuals with epilepsy: A cross-sectional survey.
作者信息
Elsayed Muaz A, El-Sayed Nuha Musa, Badi Safaa, Ahmed Mohamed H
机构信息
Department of Neurology, Faculty of Medicine, Omdurman Islamic University, Omdurman Teaching Hospital, Khartoum, Sudan.
Department of Neurology, Omdurman Teaching Hospital, Khartoum, Sudan.
出版信息
J Family Med Prim Care. 2019 Jul;8(7):2312-2317. doi: 10.4103/jfmpc.jfmpc_405_19.
BACKGROUND
Nonadherence to medication is widespread in epilepsy and other chronic diseases. Studies reporting adherence to antiepileptic medications are very limited in African countries. Adherence reports from low income African countries are few in contrast to multiple studies from high-income countries. Therefore, the aim of this study is to measure the level of adherence to antiepileptic medication in Sudanese population.
METHODS
A descriptive cross-sectional study of 96 individuals with epilepsy recruited from neurology outpatient clinics in three tertiary centers in Sudan. Data were collected by using a structured questionnaire containing Morisky Medication Adherence Scale-4 (MMAS-4) and Belief about Medication Questionnaire and analyzed by statistical package of social sciences.
RESULTS
About 35% of patients were estimated to be nonadherent. Most of the patients (93%) acknowledged their need for antiepileptic drugs. However, 35% had high concern score. Adherence is affected by attitude toward antiepileptic drugs (AEDs) and presence of side effects to AEDs. The relation between side effects and adherence was significant ( value 0.000). Furthermore, there was a statistically insignificant relation between the number of drugs used and adherence ( value 0.002). There was a significant relation between adherence, necessity mean score, concern mean score, and necessity concern differential value 0.000 for all.
CONCLUSION
Nonadherence to antiepileptic medication was reported in almost in one third of individuals in this cohort. There were statistically significant associations between nonadherence and both side effects and number of medications used in the treatment of epilepsy. Therefore, family physician should always check compliance with antiepileptic medication. Patient's education about adherence to medication through family physician may in part decrease the recurrence of epileptic seizures. Further research is needed to explore ways to increase adherence with AEDs in a low resource country like Sudan.
背景
在癫痫及其他慢性病中，不遵医嘱服药的情况普遍存在。在非洲国家，关于抗癫痫药物依从性的研究非常有限。与来自高收入国家的多项研究相比，低收入非洲国家的依从性报告较少。因此，本研究旨在衡量苏丹人群中抗癫痫药物的依从水平。
方法
对从苏丹三个三级中心的神经科门诊招募的96名癫痫患者进行描述性横断面研究。使用包含莫里斯基药物依从性量表-4（MMAS-4）和药物信念问卷的结构化问卷收集数据，并通过社会科学统计软件包进行分析。
结果
估计约35%的患者不依从。大多数患者（93%）承认他们需要抗癫痫药物。然而，35%的患者担忧得分较高。依从性受对抗癫痫药物（AEDs）的态度以及AEDs副作用的影响。副作用与依从性之间的关系显著（P值0.000）。此外，所用药物数量与依从性之间存在统计学上无显著意义的关系（P值0.002）。依从性、必要性平均得分、担忧平均得分以及必要性-担忧差异之间存在显著关系（所有P值均为0.000）。
结论
该队列中近三分之一的个体报告存在不遵医嘱服用抗癫痫药物的情况。在癫痫治疗中，不依从与副作用及所用药物数量之间存在统计学上的显著关联。因此，家庭医生应始终检查抗癫痫药物的依从情况。通过家庭医生对患者进行服药依从性教育可能会部分降低癫痫发作的复发率。在像苏丹这样资源匮乏的国家，需要进一步研究探索提高AEDs依从性的方法。
Zotero 插件