Department of Medicine, Division of Geriatric Medicine, Sir Mortimer B. Davis - Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, 3755 Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1E2, Canada.
Centre of Excellence on Longevity of McGill integrated University Health Network, Montreal, Quebec, Canada.
Geroscience. 2019 Aug;41(4):409-418. doi: 10.1007/s11357-019-00093-z. Epub 2019 Aug 28.
Motoric cognitive risk syndrome (MCR), anxio-depressive disorders (ADD), and depression are associated with cognitive complaint and slow gait speed. The study aims to examine (1) the association of ADD and depression with MCR, and (2) the influence of the type and the severity of ADD and age on this association in older adults. A total of 29,569 participants free from cognitive impairment with walking speed measure recruited at baseline in the Canadian Longitudinal Study on Aging (CLSA) Comprehensive were selected in this cross-sectional study. They were separated into different sub-groups based on their age groups (i.e., 45-54, 55-64, 65-74, and ≥ 75) and the presence of MCR. Anxiety, mood, and depressive disorders (ADD) were assessed. Depression was defined by the Center for Epidemiological Studies Depression Scale (CES-D) score ≥ 10. The overall prevalence of MCR was 7.0 % and was greater in the youngest age group (8.9 %) as compared to the other age groups (P < 0.05). There was a higher prevalence of ADD and depression in individuals with MCR compared to those without MCR for all age groups (P ≤ 0.001). Depression was significantly associated with MCR regardless of age group (odds ratio ≥ 3.65 with P ≤ 0.001). The association of ADD with MCR depended on the accumulation of disorders and not their type, and was weaker and more inconstant in the oldest age group as compared to younger age groups. MCR is associated with ADD and depression in both younger and older individuals. This association is stronger for depression in younger individuals.
运动认知风险综合征（MCR）、焦虑抑郁障碍（ADD）和抑郁与认知主诉和步态缓慢有关。本研究旨在探讨：（1）ADD 和抑郁与 MCR 的相关性；（2）ADD 的类型和严重程度以及年龄对老年人中这种相关性的影响。本横断面研究共选取了 29569 名无认知障碍且在基线时测量了步行速度的加拿大老龄化纵向研究（CLSA）综合参与者。他们根据年龄组（即 45-54、55-64、65-74 和≥75 岁）和 MCR 的存在情况分为不同的亚组。焦虑、情绪和抑郁障碍（ADD）得到评估。抑郁通过流行病学研究中心抑郁量表（CES-D）评分≥10 来定义。MCR 的总体患病率为 7.0%，在最年轻的年龄组（8.9%）中高于其他年龄组（P<0.05）。在所有年龄组中，患有 MCR 的个体比没有 MCR 的个体具有更高的 ADD 和抑郁患病率（P≤0.001）。无论年龄组如何，抑郁与 MCR 显著相关（比值比≥3.65，P≤0.001）。ADD 与 MCR 的相关性取决于疾病的积累，而不是其类型，与年轻年龄组相比，在最年长的年龄组中，这种相关性较弱且更不稳定。MCR 与年轻和年长个体的 ADD 和抑郁相关。在年轻个体中，这种相关性对抑郁更强。
