Baisa Gary A, Plum Lori, Marling Steve, Seeman Jeremy, DeLuca Hector F
Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin.
Diasorin Inc., Stillwater, Minnesota.
Physiol Rep. 2019 Aug;7(16):e14209. doi: 10.14814/phy2.14209.
Although ex vivo research suggests that vitamin D may play a role in innate and adaptive immunity, clear in vivo evidence is lacking. We have tested whether severe vitamin D deficiency alters the ability of mice to resist infection by Listeria. Our results show that vitamin D deficiency does not affect the LD of naïve mice in response to Listeria. To study the adaptive immune response, the LD for Listeria-immunized mice was determined for vitamin D-deficient and vitamin D-sufficient mice. Although the LD clearly increased by immunization with inactivated Listeria, there was no effect of vitamin D deficiency on survival of mice infected with wild-type Listeria. Thus, in this model of adaptive immunity, we could find no evidence of a role for vitamin D.
尽管体外研究表明维生素D可能在先天免疫和适应性免疫中发挥作用，但缺乏明确的体内证据。我们测试了严重维生素D缺乏是否会改变小鼠抵抗李斯特菌感染的能力。我们的结果表明，维生素D缺乏并不影响未感染过李斯特菌的小鼠对该菌的半数致死剂量。为了研究适应性免疫反应，我们测定了维生素D缺乏和维生素D充足的小鼠对经李斯特菌免疫的小鼠的半数致死剂量。尽管用灭活的李斯特菌免疫明显增加了半数致死剂量，但维生素D缺乏对感染野生型李斯特菌的小鼠的存活率没有影响。因此，在这个适应性免疫模型中，我们没有发现维生素D发挥作用的证据。
