Division Endocrinology & Diabetology, Medical Department 1, Goethe-University Hospital Frankfurt am Main, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany.
Curr Diab Rep. 2012 Dec;12(6):635-42. doi: 10.1007/s11892-012-0322-3.
Vitamin D is a secosteroid hormone that resembles other nuclear steroid hormones such as thyroid, gluco-, and mineralocorticoids, as well as gonadal effector systems. Primarily understood as a master regulator of bone and calcium/phosphate physiology, it is now increasingly recognized as orchestrating numerous aspects of cell growth and differentiation in many tissues, including those of innate and acquired immunity. This review addresses recently discovered aspects that highlight vitamin D's potential for immune intervention and how the vitamin D pathway is utilized for anti-infective and antineoplastic immunity. This provides the rationale for novel therapeutic strategies in the context both of prevention and of therapy of immune dysregulation in type 1 diabetes.
维生素 D 是一种类固醇激素，类似于其他核类固醇激素，如甲状腺、糖和矿物质皮质激素，以及性腺效应系统。最初被理解为骨骼和钙/磷生理学的主要调节剂，现在越来越多地认识到它在许多组织中协调细胞生长和分化的许多方面，包括先天和获得性免疫。这篇综述介绍了最近发现的一些方面，这些方面强调了维生素 D 对免疫干预的潜力，以及维生素 D 途径如何用于抗感染和抗肿瘤免疫。这为 1 型糖尿病中免疫失调的预防和治疗的新型治疗策略提供了依据。
