Castro Horacio Matias, Castro Azcurra Rodrigo Sebastián, Basquiera Ana Lisa, De Vito Eduardo Luis
Hospital Italiano de Buenos Aires.
Rev Fac Cien Med Univ Nac Cordoba. 2019 Aug 29;76(3):189-192. doi: 10.31053/1853.0605.v76.n3.21090.
Chronic graft versus host disease (GVHD) is a major complication of the allogeneic stem cell transplant. One of most frequent manifestations of GVHD is the cutaneous compromise with the sclerodermatous variety being the most severe. We considered that the restrictive respiratory compromise and its evolution are not well characterized. We described the functional respiratory alterations of a patient with sclerodermatous chronic GVHD and considered differential diagnosis of pulmonary restriction in this type of patient. We reported the case of a 21-year-old woman with pulmonary restriction secondary to cutaneous sclerosis which was caused by chronic GVHD. This report illustrates the importance of utilizing both functional respiratory tests and diagnosis images to accurately characterize the cause of the respiratory compromise. We believe that the functional alterations described in this case could be caused by the cutaneous disorder found.
慢性移植物抗宿主病（GVHD）是异基因干细胞移植的主要并发症。GVHD最常见的表现之一是皮肤损害，其中硬皮病样类型最为严重。我们认为，限制性呼吸功能损害及其演变尚未得到充分描述。我们描述了一名患有硬皮病样慢性GVHD患者的呼吸功能改变，并对这类患者的肺限制性疾病进行了鉴别诊断。我们报告了一例21岁女性患者，其肺部受限继发于慢性GVHD引起的皮肤硬化。本报告说明了利用呼吸功能测试和诊断影像来准确确定呼吸功能损害原因的重要性。我们认为，该病例中所描述的功能改变可能是由所发现的皮肤疾病引起的。
