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近视力障碍与虚弱:关联的证据。

Near Vision Impairment and Frailty: Evidence of an Association.

机构信息

Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

出版信息

Am J Ophthalmol. 2019 Dec;208:234-241. doi: 10.1016/j.ajo.2019.08.009. Epub 2019 Aug 26.

Abstract

PURPOSE

To examine associations between near vision impairment (NVI) and frailty.

DESIGN

Cross-sectional study.

METHODS

Setting: Nationally representative sample of noninstitutionalized United States civilians.

STUDY POPULATION

Total of 2705 older adults aged ≥60 years from National Health and Nutrition Examination Survey (1999-2002).

OBSERVATION

Presenting NVI (PNVI): near acuity worse than 20/40. Self-reported NVI (SNVI): self-reported difficulty with near vision tasks.

MAIN OUTCOME MEASURE(S): Five-item physical frailty index; participants classified as frail (≥3 criteria) and prefrail (1 or 2 criteria). Propensity score-adjusted and probability-weighted multinomial multivariable logistic regression was used to examine associations of PNVI and SNVI with frailty.

RESULTS

Of 2705 participants, 381 (10%), 160 (5%), and 106 (3%) had PNVI only, SNVI only, and PNVI+SNVI, respectively. In fully adjusted models, as compared to those without PNVI, participants with PNVI were more likely to be prefrail (odds ratio [OR] = 1.6; 95% confidence interval [CI] = 1.1, 2.3) and frail (OR = 2.5; 95% CI = 1.4, 4.3). As compared to those without SNVI, participants with SNVI were more likely to be prefrail (OR = 2.9; 95% CI = 1.8, 4.7) and frail (OR = 4.3; 95% CI = 2.2, 8.3). As compared to those without PNVI or SNVI, participants with PNVI+SNVI were more likely to be prefrail and frail (prefrail: OR = 4.0; 95% CI = 2.2, 7.2 and frail: OR = 4.5; 95% CI = 1.7,12.7).

CONCLUSIONS

Older adults with PNVI and SNVI were more likely to be prefrail and frail than those without respective NVI, suggesting that NVI is associated with frailty.

摘要

目的

探讨视力近距离损伤(NVI)与虚弱之间的关联。

设计

横断面研究。

方法

研究地点:美国全国代表性的非机构化平民样本。

研究人群

共有 2705 名年龄≥60 岁的老年人,来自全国健康和营养检查调查(1999-2002 年)。

观察指标

存在视力近距离损伤(PNVI):近视力差于 20/40。自我报告的视力近距离损伤(SNVI):自我报告的近距离视力任务困难。

主要观察指标

五项目身体虚弱指数;将参与者分为虚弱(≥3 项标准)和虚弱前期(1 或 2 项标准)。采用倾向评分调整和概率加权多项多变量逻辑回归来检验 PNVI 和 SNVI 与虚弱的关系。

结果

在 2705 名参与者中,分别有 381 名(10%)、160 名(5%)和 106 名(3%)仅有 PNVI、仅有 SNVI 和同时有 PNVI+SNVI。在完全调整的模型中,与没有 PNVI 的参与者相比,有 PNVI 的参与者更有可能处于虚弱前期(优势比[OR]为 1.6;95%置信区间[CI]为 1.1,2.3)和虚弱(OR 为 2.5;95%CI 为 1.4,4.3)。与没有 SNVI 的参与者相比,有 SNVI 的参与者更有可能处于虚弱前期(OR 为 2.9;95%CI 为 1.8,4.7)和虚弱(OR 为 4.3;95%CI 为 2.2,8.3)。与没有 PNVI 或 SNVI 的参与者相比,同时有 PNVI+SNVI 的参与者更有可能处于虚弱前期和虚弱状态(虚弱前期:OR 为 4.0;95%CI 为 2.2,7.2;虚弱:OR 为 4.5;95%CI 为 1.7,12.7)。

结论

与没有相应 NVI 的老年人相比,有 PNVI 和 SNVI 的老年人更有可能处于虚弱前期和虚弱状态,这表明 NVI 与虚弱有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f576/6888870/96c7e96c5338/nihms-1538289-f0001.jpg

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