Seger R, Wildfeuer A, Fràter-Schröder M, Linnell J C, Hitzig W H
Schweiz Med Wochenschr. 1979 Sep 29;109(37):1375-6.
Granulocytes from a boy with congenital transcobalamin II (TC II) deficiency were found to have abnormally low antibacterial activity against Staphylococcus aureus. Transfusion of normal plasma supplemented with hydroxocobalamin temporarily restored granulocyte bactericidal activity to normal. Granulocyte function was also temporarily restored by oral leucovorin. The defect appears to be causally related to the patient's TC II deficiency and indirectly to an intracellular deficiency of cobalamin and folate coenzymes [1].
一名患有先天性转钴胺素II（TC II）缺乏症的男孩的粒细胞被发现对金黄色葡萄球菌的抗菌活性异常低。输注补充了羟钴胺素的正常血浆可使粒细胞杀菌活性暂时恢复正常。口服亚叶酸钙也可使粒细胞功能暂时恢复。该缺陷似乎与患者的TC II缺乏症有因果关系，并间接与细胞内钴胺素和叶酸辅酶缺乏有关[1]。
