Honda Y, Tsunematsu K, Suzuki A, Akino T
Third Department of Internal Medicine, Sapporo Medical College, Japan.
Lung. 1988;166(5):293-301. doi: 10.1007/BF02714060.
We analyzed phospholipids of human bronchoalveolar lavage (BAL) fluids from patients with interstitial lung diseases; idiopathic pulmonary fibrosis (IPF), sarcoidosis, and eosinophilic granuloma (EG) and compared them to those of normal subjects. The content of phospholipid/ml of BAL fluid was significantly decreased in IPF. There was a significant decrease in phosphatidylglycerol (PG) and an increase in phosphatidylinositol (PI) in IPF but not in sarcoidosis and EG. Thus, the PG to PI ratio was significantly decreased in IPF. The dipalmitoyl species of phosphatidylcholine (PC) was found to be significantly decreased in IPF and sarcoidosis by molecular species analysis using high performance liquid chromatography. In contrast, the unsaturated species were increased in these diseases. The decrease in dipalmitoyl PC appeared to be a common feature in interstitial lung diseases. The changes in phospholipids in BAL fluids, especially decreases in DPPC and PG to PI ratio in IPF, appear to indicate that damage of alveolar Type II cells and/or of metabolic disturbance in pulmonary surfactant occurs in IPF.
我们分析了间质性肺疾病患者，即特发性肺纤维化（IPF）、结节病和嗜酸性肉芽肿（EG）患者的人支气管肺泡灌洗（BAL）液中的磷脂，并将其与正常受试者的进行比较。IPF患者BAL液中磷脂/毫升的含量显著降低。IPF患者中磷脂酰甘油（PG）显著减少，磷脂酰肌醇（PI）增加，而结节病和EG患者则不然。因此，IPF患者的PG与PI比值显著降低。通过高效液相色谱法进行分子种类分析发现，IPF和结节病患者中磷脂酰胆碱（PC）的二棕榈酰种类显著减少。相反，这些疾病中不饱和种类增加。二棕榈酰PC的减少似乎是间质性肺疾病的一个共同特征。BAL液中磷脂的变化，尤其是IPF中双棕榈酰卵磷脂（DPPC）和PG与PI比值的降低，似乎表明IPF中存在II型肺泡细胞损伤和/或肺表面活性物质的代谢紊乱。
