Allah Panahi Marzieh, Tahmasebi Zahra, Abbasian Vahid, Amiri Mohammad, Moradi Ali-Reza
Department of Physics, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran.
These authors contributed equally to this work.
Biomed Opt Express. 2020 Sep 15;11(10):5565-5574. doi: 10.1364/BOE.401834. eCollection 2020 Oct 1.
The myelin figure (MF) is one of the basic structures of lipids, and the study of their formation and the effect of various parameters on their growth is useful in understanding several biological processes. In this paper, we address the influence of the pH degree of the surrounding medium on MF dynamics. We introduce a tunable shearing digital holographic microscopy arrangement to obtain quantitative and volumetric information about the complex growth of MFs. Our results show that (1) the time evolution of relative length and volume changes of MFs follows a power-law, (2) the acidity facilitates the growth rate, and (3) the acidic environment causes the formation of thicker MFs.
髓鞘样结构（MF）是脂质的基本结构之一，研究其形成以及各种参数对其生长的影响有助于理解多种生物学过程。在本文中，我们探讨了周围介质的pH值对MF动态的影响。我们引入了一种可调剪切数字全息显微镜装置，以获取有关MF复杂生长的定量和体积信息。我们的结果表明：（1）MF相对长度和体积变化的时间演化遵循幂律；（2）酸性促进生长速率；（3）酸性环境导致形成更厚的MF。
