Grillot-Courvalin C, Hivroz C, Brouet J C
Laboratory of Immunochemistry and Immunopathology, INSERM U108, Paris, France.
Nouv Rev Fr Hematol (1978). 1988;30(5-6):301-4.
We report here the study of early events following surface Ig cross-linking such as Ca2+ mobilization and IP3 generation, in chronic lymphocytic leukemia (CLL) B cells. Those leukemic populations were previously shown to be frozen at different stages of activation with unique requirements for proliferation. The study reported here disclosed 3 patterns of response in terms of Ca2+ mobilization and proliferation. These results are interpreted in terms of differential anti-mu signalling on B cells at different stages of activation.
我们在此报告对慢性淋巴细胞白血病（CLL）B细胞表面免疫球蛋白（Ig）交联后早期事件的研究，如钙离子（Ca2+）动员和肌醇三磷酸（IP3）生成。这些白血病细胞群体先前已显示在激活的不同阶段停滞，对增殖有独特需求。此处报告的研究揭示了在Ca2+动员和增殖方面的3种反应模式。这些结果根据B细胞在激活不同阶段的抗μ信号差异来解释。
