Gene Expression in Hippocampal Long-Term Potentiation.

Recent work on hippocampal LTP has focused on gene expression induced with high-frequency stimulation, as well as the signal transduction cascades responsible for the induction of these genes. Many scenarios for LTP lasting for greater than 5 hours include some or all of the following processes: 1) tagging of potentiated synapses, possibly by phosphorylation; 2) signaling to the nucleus; 3) kinase cascades and transcription factors in the nucleus;, 4) expression of immediate-early genes and/or synaptic proteins; and, finally, 5) targeting of newly synthesized proteins (or RNAs) to the potentiated synapses (and not to the unpotentiated synapses). Unfortunately, most scenarios proposed for the late-phase expression of LTP are still highly speculative at this time. A critical review of the literature relating to the role of gene expression in hippocampal LTP and a discussion of recent work on the subject will be presented.