Dudek Serena M, Fields R Douglas
Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, Maryland.
Neuroscientist. 1999 Sep 1;5(5):275-279. doi: 10.1177/107385849900500512.
Recent work on hippocampal LTP has focused on gene expression induced with high-frequency stimulation, as well as the signal transduction cascades responsible for the induction of these genes. Many scenarios for LTP lasting for greater than 5 hours include some or all of the following processes: 1) tagging of potentiated synapses, possibly by phosphorylation; 2) signaling to the nucleus; 3) kinase cascades and transcription factors in the nucleus;, 4) expression of immediate-early genes and/or synaptic proteins; and, finally, 5) targeting of newly synthesized proteins (or RNAs) to the potentiated synapses (and not to the unpotentiated synapses). Unfortunately, most scenarios proposed for the late-phase expression of LTP are still highly speculative at this time. A critical review of the literature relating to the role of gene expression in hippocampal LTP and a discussion of recent work on the subject will be presented.
近期关于海马体长时程增强（LTP）的研究聚焦于高频刺激诱导的基因表达，以及负责这些基因诱导的信号转导级联反应。许多持续超过5小时的LTP情况包括以下部分或全部过程：1）对增强突触进行标记，可能通过磷酸化；2）向细胞核发出信号；3）细胞核中的激酶级联反应和转录因子；4）即刻早期基因和/或突触蛋白的表达；最后，5）将新合成的蛋白质（或RNA）靶向到增强突触（而非未增强突触）。不幸的是，目前提出的大多数关于LTP晚期表达的情况仍极具推测性。本文将对与基因表达在海马体LTP中的作用相关的文献进行批判性综述，并讨论该主题的近期研究工作。
