Lu Cuncun, Bing Zhitong, Bi Zhijiang, Liu Ming, Lu Tingting, Xun Yangqin, Wei Zhipeng, Yang Kehu
Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Evidence-based Social Science Center, School of Public Health, Lanzhou University, Lanzhou, China.
Evid Based Complement Alternat Med. 2019 Aug 1;2019:1704816. doi: 10.1155/2019/1704816. eCollection 2019.
Network pharmacology (NP) has become an increasingly important focus in the drug research field over the past decade. However, no study to date has mapped the current status of NP. Therefore, we performed a bibliometric study to evaluate the top 100 cited papers on NP.
We searched the Web of Science Core Collection from its inception to February 25, 2019, using the terms "network pharmacology" and "systems pharmacology." Key data, including title, publication year, number of citations, authors, countries/regions, organizations, and journals, were retrieved and analyzed using Excel 2016 and VOSviewer 1.6.10.
The total number of citations for the 100 cited papers ranged from 21 to 1,238, published in 53 journals, from 2005 to 2017. The top three journals with the most publications on NP were ( = 8, IF2017 = 6.544), ( = 8, IF2017 = 3.115), and ( = 7, IF2017 = 2.766). Most published articles were from the USA ( = 41) and China ( = 35). The most active author was from the Northwest A&F University, and of the 100 publications, 14 listing his name. The most frequently used substantive terms included "drug discovery," "traditional Chinese medicine (TCM)," "in-vitro," "cancer," and "cardiovascular disease." . The USA and China made the greatest contribution to NP research. The current NP research mainly focused on NP methods (including experimental validation) and using them to explore the molecular mechanisms of TCM for some critical diseases such as cardiovascular diseases and cancers. Furthermore, we believe some guidelines should be developed to regulate NP studies.
在过去十年中，网络药理学（NP）已成为药物研究领域日益重要的焦点。然而，迄今为止尚无研究描绘NP的现状。因此，我们进行了一项文献计量学研究，以评估NP领域被引用次数排名前100的论文。
我们在科学网核心合集数据库中，从其创建到2019年2月25日，使用检索词“网络药理学”和“系统药理学”进行检索。检索并使用Excel 2016和VOSviewer 1.6.10分析关键数据，包括标题、出版年份、被引用次数、作者、国家/地区、机构和期刊。
这100篇被引用论文的总被引用次数在21至1238次之间，发表于2005年至2017年的53种期刊上。NP领域发表论文最多的前三本期刊分别是（发表8篇，2017年影响因子=6.544）、（发表8篇，2017年影响因子=3.115）和（发表7篇，2017年影响因子=2.766）。大多数发表文章来自美国（41篇）和中国（35篇）。最活跃的作者是西北农林科技大学的，在这100篇出版物中，有14篇列出了他的名字。最常用的实质性术语包括“药物发现”、“中药（TCM）”、“体外”、“癌症”和“心血管疾病”。美国和中国对NP研究贡献最大。当前的NP研究主要集中在NP方法（包括实验验证）以及使用这些方法探索中药对心血管疾病和癌症等一些关键疾病的分子机制。此外，我们认为应该制定一些指南来规范NP研究。
