丝裂原活化蛋白激酶信号转导通路参与电针治疗不同疾病的机制
The Mechanism of MAPK Signal Transduction Pathway Involved with Electroacupuncture Treatment for Different Diseases.
作者信息
Du Weibin, Hu Huahui, Zhang Jiangsong, Bao Guanai, Chen Rongliang, Quan Renfu
机构信息
Research Institute of Orthopedics, The Affiliated Jiangnan Hospital of Zhejiang Chinese Medical University, Hangzhou 312001, China.
Research Institute of Acupuncture, Zhejiang Chinese Medical University, Hangzhou 310058, China.
出版信息
Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019.
The mitogen-activated protein kinase (MAPK) signal transduction pathway plays an important role in the regulation of various diseases, such as cardiovascular and cerebrovascular diseases, and takes part in anti-inflammatory effects, analgesic effects, protection against injury, and maintenance of gastrointestinal functions. Electroacupuncture therapy is an external therapy used in traditional Chinese medicine. By adding external electrical stimulation to traditional acupuncture, the stimulus gets doubled and the therapeutic efficacy gets enhanced accordingly. It combines the benefits of both acupuncture and electrical stimulation. In recent years, some studies have explored the molecular mechanisms of MAPK signal pathways involved with electroacupuncture treatment. Based on these recent studies, this article summarizes the mechanisms of MAPK signal transduction pathways involved with electroacupuncture treatment. This adds great value to the studies of molecular mechanisms of electroacupuncture treatment and also provides an effective reference for its clinical use.
丝裂原活化蛋白激酶（MAPK）信号转导通路在多种疾病的调控中发挥重要作用，如心脑血管疾病，并且参与抗炎作用、镇痛作用、抗损伤保护以及胃肠功能的维持。电针疗法是中医使用的一种外治疗法。通过在传统针刺基础上增加外部电刺激，刺激加倍，治疗效果相应增强。它结合了针刺和电刺激两者的优点。近年来，一些研究探索了电针治疗涉及的MAPK信号通路的分子机制。基于这些最新研究，本文总结了电针治疗涉及的MAPK信号转导通路的机制。这为电针治疗的分子机制研究增添了重要价值，也为其临床应用提供了有效的参考。
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