Duarte-Silva M, Guerra-Pinto F, Camelo-Barbosa N, Beja-da-Costa P
Department of Orthopaedics and Traumatology, Hospital de Cascais Dr. José de Almeida, Cascais, Portugal.
Department of Orthopaedics, Hospital Pedro Hispano, Matosinhos, Portugal.
Malays Orthop J. 2019 Jul;13(2):38-41. doi: 10.5704/MOJ.1907.007.
Meniscectomy is the most common surgery in orthopaedics. The absence of meniscal tissue might be related to irreversible damage to the articular cartilage. Meniscal replacement is a tissue-engineering technique for post-meniscectomy syndrome. Its success depends on the implant integration which was vastly proven in animal model studies. Histological evidence is hard to obtain in humans due to ethical issues. We report a clinical case in which a collagen scaffold meniscal implant was harvested six months after implantation due to mechanical failure. Histological analysis was performed revealing vascularisation not only of the peripheral attachment of the implant but also on the anterior horn. These morphologic findings demonstrate that this implant allows the colonisation by precursor cells and vessels, leading to the formation of a fully functional tissue. This present report is one of the few independent reports of scaffold biological integration in the literature.
半月板切除术是骨科最常见的手术。半月板组织的缺失可能与关节软骨的不可逆损伤有关。半月板置换是一种用于治疗半月板切除术后综合征的组织工程技术。其成功取决于植入物的整合，这在动物模型研究中已得到充分证明。由于伦理问题，很难在人体中获得组织学证据。我们报告了一例临床病例，一名患者因机械故障在植入胶原支架半月板植入物六个月后将其取出。进行了组织学分析，结果显示不仅植入物的周边附着部位有血管化现象，前角也有血管化。这些形态学发现表明，这种植入物允许前体细胞和血管定植，从而形成功能完全正常的组织。本报告是文献中为数不多的关于支架生物整合的独立报告之一。
