Marusak Hilary A, Harper Felicity W, Taub Jeffrey W, Rabinak Christine A
Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Population Studies & Disparities Research Program, Karmanos Cancer Institute, Detroit, MI 48201, USA.
Int J Hematol Oncol. 2019 Jul 11;8(2):IJH17. doi: 10.2217/ijh-2019-0002.
This review examines the neurobiological effects of pediatric cancer-related posttraumatic stress symptoms (PTSS). We first consider studies on prevalence and predictors of childhood cancer-related PTSS and compare these studies to those in typically developing (i.e., noncancer) populations. Then, we briefly introduce the brain regions implicated in PTSS and review neuroimaging studies examining the neural correlates of PTSS in noncancer populations. Next, we present a framework and recommendations for future research. In particular, concurrent evaluation of PTSS and neuroimaging, as well as sociodemographic, medical, family factors, and other life events, are needed to uncover mechanisms leading to cancer-related PTSS. We review findings from neuroimaging studies on childhood cancer and one recent study on cancer-related PTSS as a starting point in this line of research.
本综述探讨了儿童癌症相关创伤后应激症状（PTSS）的神经生物学效应。我们首先考量关于儿童癌症相关PTSS的患病率及预测因素的研究，并将这些研究与典型发育（即非癌症）人群的研究进行比较。然后，我们简要介绍与PTSS相关的脑区，并综述在非癌症人群中检测PTSS神经关联的神经影像学研究。接下来，我们提出了一个未来研究的框架和建议。特别是，需要同时评估PTSS和神经影像学，以及社会人口统计学、医学、家庭因素和其他生活事件，以揭示导致癌症相关PTSS的机制。我们回顾了关于儿童癌症的神经影像学研究结果以及一项近期关于癌症相关PTSS的研究，作为这一研究方向的起点。
