印度村民中安替比林清除率
Antipyrene clearance in Indian villagers.
作者信息
Desai N K, Sheth U K, Mucklow J C, Fraser H S, Bulpitt C J, Jones S W, Dollery C T
出版信息
Br J Clin Pharmacol. 1980 Apr;9(4):387-94. doi: 10.1111/j.1365-2125.1980.tb01066.x.
Abstract
1 Antipyrine clearance has been measured using saliva samples in 50 Maharashtrans from a village to the north of Bombay. 2 All subjects were very lean and were also anaemic probably as a result of hookworm infestation. 3 Antipyrine clearance was 36% faster than in White Londoners studied previously and more than twice as fast as in Asian immigrants living in London. 4 Clearance was 25% faster in men than in women but volume of distribution was also greater in men and mean half-lives did not differ significantly between the sexes. 5 There was a negative correlation between antipyrine clearance and haemoglobin concentration. 6 The study has identified geographic differences in antipyrine metabolism which could be clinically important. The role of anaemia merits further study.
摘要
- 在孟买以北一个村庄的50名马哈拉施特拉邦人中，使用唾液样本测量了安替比林清除率。2. 所有受试者都非常消瘦，可能由于钩虫感染而贫血。3. 安替比林清除率比之前研究的伦敦白人快36%，比居住在伦敦的亚洲移民快两倍多。4. 男性的清除率比女性快25%，但分布容积男性也更大，两性的平均半衰期无显著差异。5. 安替比林清除率与血红蛋白浓度呈负相关。6. 该研究确定了安替比林代谢的地理差异，这可能具有临床重要性。贫血的作用值得进一步研究。
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Antipyrene clearance in Indian villagers.印度村民中安替比林清除率
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本文引用的文献
1
Hookworm disease and malabsorption.钩虫病与吸收不良。
Gastroenterology. 1962 Feb;42:148-56.
2
Effect of age and sex on human drug metabolism.年龄和性别对人体药物代谢的影响。
Br Med J. 1971 Sep 11;3(5775):607-9. doi: 10.1136/bmj.3.5775.607.
3
Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy.双胞胎中去甲替林的稳态血浆水平：遗传因素和药物治疗的影响。
Br Med J. 1969 Dec 27;4(5686):764-8. doi: 10.1136/bmj.4.5686.764.
4
Comparison of plasma levels of antipyrine, tolbutamide, and warfarin after oral and intravenous administration.口服和静脉注射后安替比林、甲苯磺丁脲和华法林的血浆水平比较。
Clin Pharmacol Ther. 1974 Dec;16(6):1059-65. doi: 10.1002/cpt19741661059.
5
The disposition of propranolol. 8. General implications of the effects of liver blood flow on elimination from the perfused rat liver.普萘洛尔的处置。8. 肝血流量对灌注大鼠肝脏消除作用的一般影响
Drug Metab Dispos. 1973 Sep-Oct;1(5):687-90.
6
Genetic and environmental factors affecting drug response in man.影响人类药物反应的遗传和环境因素。
Fed Proc. 1972 Jul-Aug;31(4):1253-69.
7
Antipyrine metabolism in man: influence of age, alcohol, caffeine, and smoking.人体中安替比林的代谢：年龄、酒精、咖啡因和吸烟的影响。
Clin Pharmacol Ther. 1975 Oct;18(4):425-32. doi: 10.1002/cpt1975184425.
8
Interactions between nutritional factors and drug biotransformations in man.人体营养因素与药物生物转化之间的相互作用。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2501-4. doi: 10.1073/pnas.73.7.2501.
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