Komaki R, Cox J D, Hansen R M, Gunn W G, Greenberg M
Cancer. 1984 Oct 15;54(8):1699-704. doi: 10.1002/1097-0142(19841015)54:8<1699::aid-cncr2820540836>3.0.co;2-e.
Three patients with primary malignant lymphoma of the uterine cervix are reported and the literature is reviewed. All of the patients in the current cases presented with irregular menstruation. Two patients were found to have diffuse histiocytic lymphoma, and one patient had diffuse mixed lymphoma. Histologic diagnosis was confirmed by outside expert pathologists in all cases. In spite of locally advanced disease according to FIGO's classification (Stage IVA-2 and Stage IIB-1), they responded well to external irradiation, and had control of tumor within the pelvis. All are alive at 13, 7, and 3 years, respectively, after the completion of irradiation. One patient developed disseminated disease 4.25 years after the completion of external irradiation, but was successfully treated with combination chemotherapy for 2 years, and is alive at 6.75 years after the completion of chemotherapy without disease. Review of the other 21 cases reported in the literature reveals that 14 were free of disease after treatment. The importance of distinguishing malignant lymphoma from undifferentiated carcinoma or sarcoma is emphasized since cervical malignant lymphoma can be successfully treated with irradiation in spite of locally advanced disease.
本文报告了3例原发性子宫颈恶性淋巴瘤患者，并对相关文献进行了综述。所有这些病例中的患者均表现为月经不规律。2例患者被诊断为弥漫性组织细胞淋巴瘤，1例为弥漫性混合性淋巴瘤。所有病例的组织学诊断均由外部专家病理学家确认。尽管根据国际妇产科联盟（FIGO）的分类，这些患者属于局部晚期疾病（IVA-2期和IIB-1期），但他们对外部放疗反应良好，盆腔内肿瘤得到控制。放疗结束后，3例患者分别已存活13年、7年和3年。1例患者在外部放疗结束4.25年后出现播散性疾病，但接受了2年的联合化疗并取得成功，化疗结束后已存活6.75年，目前无疾病。对文献中报道的其他2例病例进行回顾发现，14例患者治疗后无疾病。强调了区分恶性淋巴瘤与未分化癌或肉瘤的重要性，因为尽管子宫颈恶性淋巴瘤属于局部晚期疾病，但通过放疗仍可成功治疗。
