Department of Ear Nose Throat, Acibadem Healthcare Group, Acibadem Kocaeli Hospital, Izmit, Kocaeli, Turkey.
Department of Ear Nose Throat, Marmara University, Ministry of Health, Pendik Education and Research Hospital, Istanbul, Turkey.
Eur Arch Otorhinolaryngol. 2019 Nov;276(11):3123-3130. doi: 10.1007/s00405-019-05605-3. Epub 2019 Aug 29.
Rhinitis medicamentosa is drug-induced rhinitis which occurs by prolonged and overdose usage of topical nasal decongestants. There is not much of treatment choice rather than nasal steroids. In this pathological study, we have been aimed to represent the healing effects of xylitol on damaged nasal mucosa due to rhinitis medicamentosa.
30 Wistar rats were separated into 5 groups. During 2 months, oxymetazoline was given to the first group, and saline was given to second group intranasally. First and second group animals were examined at the end of 2 months and rhinitis medicamentosa was detected. Oxymetazoline was given to the third, fourth, and fifth groups during 2 months. Then xylitol solution, mometasone, and saline were applied, respectively, for 15 days. After the experiment, rats' nasal mucosas were evaluated histopathologically.
Xylitol and mometasone were found to be more effective than the control group in terms of histopathological changes. Effectivity of xylitol and mometasone was compared and not a significant value was determined.
According to the results, xylitol solution is effective as mometasone, usable and well-priced in the treatment of rhinitis medicamentosa. More comprehensive and ultrastructural studies on animals and human studies with rhinometric evaluation should be performed.
药物性鼻炎是由于长期、过量使用局部鼻减充血剂引起的鼻炎。除了鼻用类固醇外，治疗选择并不多。在这项病理研究中，我们旨在表明木糖醇对药物性鼻炎引起的鼻黏膜损伤的愈合作用。
将 30 只 Wistar 大鼠分为 5 组。第一组在 2 个月期间给予羟甲唑啉，第二组给予鼻腔生理盐水。在 2 个月结束时检查第一组和第二组动物，并检测药物性鼻炎。在 2 个月期间，第三、第四和第五组给予羟甲唑啉。然后分别应用木糖醇溶液、糠酸莫米松和生理盐水 15 天。实验结束后，对大鼠的鼻黏膜进行组织病理学评估。
在组织病理学变化方面，木糖醇和糠酸莫米松均比对照组更有效。木糖醇和糠酸莫米松的疗效进行了比较，未确定有显著差异。
根据结果，木糖醇溶液在治疗药物性鼻炎方面与糠酸莫米松一样有效，可使用且价格合理。应在动物和人类研究中进行更全面和超微结构研究，并进行鼻测量评估。
