Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Reproductive Biotechnology, Reproductive Biomedicine Research Centre, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
Phytother Res. 2019 Dec;33(12):3203-3211. doi: 10.1002/ptr.6493. Epub 2019 Aug 30.
Infertility is a major, worldwide problem that is affected, and mediated, by several factors, in particular, oxidative stress. Thus, the aim of this study was to evaluate the effect of lycopene supplementation on spermatogram and seminal oxidative stress. In this randomized, double-blind, placebo-controlled trial study, 44 infertile men with oligozoospermia were randomly divided into two groups: The experimental group was supplemented with 25 mg of lycopene, and the control group received placebo for 12 weeks. Anthropometric, physical activity and dietary assessment, semen analysis, total antioxidant capacity (TAC), malondialdehyde, and glutathione peroxidase were measured pre- and post-intervention. At the end of the study, there was a significant increase in total sperm count and concentration in the lycopene group, and the latter total count remained significant after adjustment (p < .05). Intragroup analysis showed a significant increase in ejaculate volume, total sperm count, concentration total motility, nonprogressive, and nonmotility in lycopene group (p < .05). The TAC changes, in both groups, remained significant after adjustment (p < .05). Also, within-group analysis showed a significant increase in TAC levels (p < .05). Lycopene supplement can improve sperm parameters and oxidative stress biomarkers in oligozoospermia infertile men; however, further studies with larger sample size and duration are required.
不育是一个全球性的重大问题，受到多种因素的影响和介导，特别是氧化应激。因此，本研究旨在评估番茄红素补充对精液分析和精液氧化应激的影响。在这项随机、双盲、安慰剂对照试验研究中，44 名少精子症的不育男性被随机分为两组：实验组补充 25 毫克番茄红素，对照组服用安慰剂 12 周。在干预前后测量了人体测量学、体力活动和饮食评估、精液分析、总抗氧化能力（TAC）、丙二醛和谷胱甘肽过氧化物酶。研究结束时，番茄红素组的总精子数和浓度有显著增加，后者的总计数在调整后仍保持显著（p<.05）。组内分析显示，番茄红素组的精液量、总精子数、浓度、总活力、非进展性和非活力均有显著增加（p<.05）。两组的 TAC 变化在调整后仍保持显著（p<.05）。此外，组内分析显示 TAC 水平显著升高（p<.05）。番茄红素补充可以改善少精子症不育男性的精子参数和氧化应激生物标志物；然而，需要进一步进行更大样本量和更长时间的研究。
