Learning Key Laboratory for Pharmacoproteomics of Hunan Province, Institute of Pharmacy and Pharmacology, University of South China , Hengyang , China.
Hunan Province Key Laboratory for Antibody-Based Drug and Intelligent Delivery System, Hunan University of Medicine , Huaihua , China.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3621-3630. doi: 10.1080/21691401.2019.1657875.
With the arrival of the precision medicine and personalized treatment era, targeted therapy that improves efficacy and reduces side effects has become the mainstream approach of cancer treatment. Antibody fragments that further enhance penetration and retain the most critical antigen-specific binding functions are considered the focus of research targeting cancer imaging and therapy. Thanks to the superior penetration and rapid blood clearance of antibody fragments, antibody fragment-based imaging agents enable efficient and sensitive imaging of tumour sites. In tumour-targeted therapy, antibody fragments can directly inhibit tumour proliferation and growth, serve as an ideal carrier for delivery of anti-tumour drugs, or manipulate the immune system to eliminate tumour cells. In this review, the excellent physicochemical properties and the basic structure of antibody fragments are expressly depicted , the progress of antibody fragments in cancer therapy and imaging are thoroughly summarized, and the future development of antibody fragments is predicted.
随着精准医学和个性化治疗时代的到来，提高疗效、降低副作用的靶向治疗已成为癌症治疗的主流方法。进一步增强穿透性并保留最关键抗原特异性结合功能的抗体片段被认为是癌症成像和治疗靶向研究的重点。由于抗体片段具有优越的穿透性和快速的血液清除率，基于抗体片段的成像剂能够高效、灵敏地对肿瘤部位进行成像。在肿瘤靶向治疗中，抗体片段可以直接抑制肿瘤的增殖和生长，作为递送抗肿瘤药物的理想载体，或操纵免疫系统来消除肿瘤细胞。在这篇综述中，明确描述了抗体片段的优异理化性质和基本结构，全面总结了抗体片段在癌症治疗和成像方面的进展，并对抗体片段的未来发展进行了预测。
