氯丙嗪浸渍导管作为控制生物膜相关尿路感染的潜在策略。
Chlorpromazine-impregnated catheters as a potential strategy to control biofilm-associated urinary tract infections.
机构信息
Department of Pathology & Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Center, Federal University of Ceará, Rua Cel, Nunes de Melo, 1315 - Rodolfo Teófilo - CEP 60430-275, Fortaleza, Ceará, Brazil.
Department of Pathology & Legal Medicine, Postgraduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Federal University of Ceará, Rua Cel, Nunes de Melo, 1315 - Rodolfo Teófilo - CEP 60430-275, Fortaleza, Ceará, Brazil.
出版信息
Future Microbiol. 2019 Aug;14:1023-1034. doi: 10.2217/fmb-2019-0092.
This study proposes the impregnation of Foley catheters with chlorpromazine (CPZ) to control biofilm formation by , and . The minimum inhibitory concentrations (MICs) for CPZ and the effect of CPZ on biofilm formation were assessed. Afterward, biofilm formation and the effect of ciprofloxacin and meropenem (at MIC) on mature biofilms grown on CPZ-impregnated catheters were evaluated. CPZ MIC range was 39.06-625 mg/l. CPZ significantly reduced (p < 0.05) biofilm formation and on impregnated catheters. In addition, CPZ-impregnation potentiated the antibiofilm activity of ciprofloxacin and meropenem. These findings bring perspectives for the use of CPZ as an adjuvant for preventing and treating catheter-associated urinary tract infections.
本研究提出用氯丙嗪（CPZ）浸渍 Foley 导管，以控制 和 生物膜的形成。评估了 CPZ 的最小抑菌浓度（MIC）及其对生物膜形成的影响。随后，评估了 CPZ 浸渍导管上形成的成熟生物膜对环丙沙星和美罗培南（MIC）的生物膜形成和作用。CPZ 的 MIC 范围为 39.06-625mg/L。CPZ 显著降低（p<0.05）生物膜形成和浸渍导管上的生物膜形成。此外，CPZ 浸渍增强了环丙沙星和美罗培南的抗生物膜活性。这些发现为 CPZ 作为预防和治疗导管相关尿路感染的辅助剂提供了新的视角。
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